N-苄氧羰基-L-苯丙氨酸对硝基苯酯合成路线 （共 26 条）
反应条件
sodium hydroxide in N,N-dimethyl-formamide
T=20°C;
参考文献
Sobirov, M.M.; Khalikov, Sh.Kh.; Saidov, S.S.; Kodirov, M.Z.; Zaitsev, S.V.; et al.
Russian Journal of Bioorganic Chemistry, 1994 , vol. 20, # 7 p. 397 - 405
Bioorganicheskaya Khimiya, 1994 , vol. 20, # 7 p. 740 - 750
反应条件
1: 85 percent / Et3N, hydroxybenzotriazole (HOBt) / CH2Cl2 / 16 h
2: 45percent HBr/CH3COOH / 0.5 h
3: Et3N, hydroxybenzotriazole (HOBt) / dimethylformamide / 16 h
4: 87 percent / 4 N aq. NaOH / methanol / 1 h / 0 °C
5: 1.) Et3N, 2.) hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCC) / 1.) DMF, 0.5 h, 2.) DMF, RT, 16 h
View Scheme
参考文献
Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania
Polish Journal of Chemistry, 1980 , vol. 54, # 9 p. 1707 - 1712
反应条件
in N,N-dimethyl-formamide
T=20°C; 15 h; Yield given;
参考文献
Ovchinnikov, Mikhail V.; Bespalova, Zhanna D.; Molokoedov, Aleksandr S.; Revenko, Inna V.; Sepetov, Nikolai F.; et al
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 3 p. 784 - 795
反应条件
S-1-methylheptanol; borate buffer; water; Bis-2-octyl sodium sulphosuccinate; sodium hydroxide in n-heptane
T=25°C; kL; Rate constant;
参考文献
Andriamanampisoa, R.; Boyer, B.; Lamity, G.; Roque, J. P.
Tetrahedron, 1987 , vol. 43, # 1 p. 77 - 84
反应条件
1,4-dioxane; methanol; phosphate buffer; N,N-didodecyl-Nα-lt;6-(trimethylammonio)hexanoylgt;histidinamide
T=19.9°C; other catalysts (N-dodecyl-Nα-<6-(trimethylammonio)hexanoyl>histidinamide bromide (less effective and enantioselective), alkali); ΔG<*>, ΔH<*>, ΔS<*>; Rate constantKineticsThermodynamic data;
参考文献
Murakumi, Yukito; Nakano, Akio; Yoshimatsu, Akira; Fukuya, Kiyoshi
Journal of the American Chemical Society, 1981 , vol. 103, # 3 p. 728 - 730
反应条件
phosphate buffer; borate buffer; acetate buffer; Tubocurarine in acetonitrile
T=25°C; hydrolysis at various pH; Product distributionRate constant;
参考文献
Godoy-Alcantar, Carolina; Nelen, Marina I.; Eliseev, Alexey V.; Yatsimirsky, Anatoly K.
Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 2 p. 353 - 361
