2,3-二氯吡啶并[2,3-b]吡嗪合成路线 （共 5 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in chloroform 24 h; Reflux;
参考文献
Gong, Young-Dae; Dong, Mi-Sook; Lee, Sang-Bum; Kim, Nayeon; Bae, Mi-Seon; Kang, Nam-Sook
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5639 - 5647
反应条件
1: 85 percent / aq. HCl / 6 h / Heating 2: 80 percent / SOCl2; DMF / 10 h / Heating View Scheme
参考文献
NOVARTIS AG; CHARLTON, Steven, John; LEBLANC, Catherine; MCKEOWN, Stephen, Carl
Patent: WO2012/7539 A1, 2012 ;
WO 2012/007539 A1
反应条件
1: With hydrogenchloride in water 2: With thionyl chloride; N,N-dimethyl-formamide
参考文献
Unciti-Broceta, Asier; Pineda-de-las-Infantas, Maria Jose; Gallo, Miguel Angel; Espinosa, Antonio
Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2262 - 2264
反应条件
1: 85 percent / hydrazine monohydrate / propan-2-ol / 3 h / 20 °C 2: 89 percent / sodium hydroxide / H2O / 0.42 h / Heating View Scheme
参考文献
Unciti-Broceta, Asier; Pineda De Las Infantas, Maria J.; Gallo, Miguel A.; Espinosa, Antonio
Chemistry - A European Journal, 2007 , vol. 13, # 6 p. 1754 - 1762
反应条件
1: 78 percent / hydrazine monohydrate / ethanol / 1 h / 0 °C 2: 81 percent / sodium hydroxide / H2O / 0.25 h / 60 °C View Scheme
参考文献
Unciti-Broceta, Asier; Pineda De Las Infantas, Maria J.; Gallo, Miguel A.; Espinosa, Antonio
Chemistry - A European Journal, 2007 , vol. 13, # 6 p. 1754 - 1762
