2,4,6-三甲基苯甲腈合成路线 （共 81 条）
反应条件
hydrogenchloride; hydroxylamine hydrochloride in ethanol 4 h; Heating;
参考文献
Enthaler, Stephan; Weidauer, Maik; Schroeder, Fanny
Tetrahedron Letters, 2012 , vol. 53, # 7 p. 882 - 885
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With n-butyllithium in tetrahydrofuran; hexane T=-70 - 0°C; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=0°C; 1 h; 3: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 5 p. 958 - 964
反应条件
1: With magnesium in tetrahydrofuran T=20°C; 2 h; 2: With N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 2 h; 3: With ammonia; iodine in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2013 , vol. 69, # 5 p. 1462 - 1469
反应条件
rhenic(VII) acid in water; toluene 24 h; Heating;
参考文献
Ishihara, Kazuaki; Furuya, Yoshiro; Yamamoto, Hisashi
Angewandte Chemie - International Edition, 2002 , vol. 41, # 16 p. 2983 - 2986
反应条件
1: N,N-dimethyl-formamide With trifluoromethylsulfonic anhydride T=0°C; 0.5 h; 2: 1,3,5-trimethyl-benzene in N,N-dimethyl-formamide Vilsmeier-Haack reaction; 65 h; Reflux; 3: With ammonia; iodine in tetrahydrofuran; water; N,N-dimethyl-formamide T=20°C; 3 h; regioselective reaction;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4588 - 4595
反应条件
copper(I) thiophene-2-carboxylate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane T=100°C; 12 h;
参考文献
Zhang, Zhihui; Liebeskind, Lanny S.
Organic Letters, 2006 , vol. 8, # 19 p. 4331 - 4333
反应条件
1,2-dibromo-1,1,2,2-tetrachloroethane; triethylamine; triphenylphosphine in 1,2-dichloro-ethane T=0°C; 0.0166667 h;
参考文献
Bringmann, Gerhard; Schneider, Stephan
Synthesis, 1983 , # 2 p. 139 - 141
反应条件
pyridine; N-chloro-succinimide in acetonitrile T=20°C;
参考文献
Gucma, Miroslaw; Golebiewski, W. Marek
Synthesis, 2008 , # 13 p. 1997 - 1999
反应条件
magnesium monoperoxyphthalate hexahydrate in methanol T=0°C; 0.0833333 h;
参考文献
Fernandez, Rosario; Gasch, Consolacion; Lassaletta, Jose-Maria; Llera, Jose-Manuel; Vazquez, Juan
Tetrahedron Letters, 1993 , vol. 34, # 1 p. 141 - 144
反应条件
tert.-butyl lithium in tetrahydrofuran; hexane T=-94°C;
参考文献
Rutan, Kimberly J.; Heldrich, Frederick J.; Borges, Lawrence F.
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2948 - 2950
