4-溴-1-甲基-1H-咪唑合成路线 （共 7 条）
反应条件
sodium hydroxide in tetrahydrofuran T=7 - 20°C;
参考文献
WO2011/150156 A2, ;
Page/Page column 103 ;
WO 2011/150156 A2
反应条件
n-butyllithium in diethyl ether T=-50°C;
参考文献
Borai, M. El; Moustafa, A. H.; Anwar, M.; Hay, F. I. Abdel
Polish Journal of Chemistry, 1981 , vol. 55, # 7/8 p. 1659 - 1665
反应条件
in methanol T=-25°C; 120 h;
参考文献
Bulletin des Societes Chimiques Belges, , vol. 97, # 8-9 p. 573 - 598
反应条件
sodium sulfite 24 h; Reflux;
参考文献
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; PROVID PHARMACEUTICALS INC.; EBRIGHT, Richard H.; EBRIGHT, Yon W.; SHEN, Juan; BACCI, James; HIEBEL, Anne-Cecile; SOLVIBILE, William; SELF, Christopher; OLSON, Gary
Patent: WO2013/192352 A1, 2013 ;
Location in patent: Page/Page column 117 ;
反应条件
T=235 - 245°C; P=28 Torr;
参考文献
Heterocycles, , vol. 33, # 1 p. 21 - 26
反应条件
n-butyllithium in diethyl ether; hexane T=-70°C; 0.666667 h; Yield given. Yields of byproduct given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 735 - 739
反应条件
Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1139 - 1145
