DHA 甲酯 Fame 22:6n-3 全顺-4,7,10,13,16,19-二十二碳六烯酸甲酯合成路线 （共 26 条）
反应条件
1: 95 percent / acetonitrile / Heating 2: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: 86 percent / LiAlH4 / tetrahydrofuran / -70 °C 2: 94 percent / CBr4, Ph3P / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h 3: 95 percent / acetonitrile / Heating 4: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: 100 percent / H+ / tetrahydrofuran 2: 86 percent / LiAlH4 / tetrahydrofuran / -70 °C 3: 94 percent / CBr4, Ph3P / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h 4: 95 percent / acetonitrile / Heating 5: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: H+ / tetrahydrofuran 2: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: TsOH / methanol 2: PBr3, Py / diethyl ether 3: (i) EtMgBr, THF, (ii) /BRN= 1840948/, CuCl, (iii) TsOH, MeOH 4: PBr3, Py / diethyl ether 5: (i) EtMgBr, Et2O, (ii) /BRN= 1841586/, CuCl 6: (i) H2, Lindlar catalyst, EtOH, (ii) /BRN= 102415/, MeOH, Et2O View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 1015 - 1025
反应条件
1: (i) EtMgBr, THF, (ii) /BRN= 1840948/, CuCl, (iii) TsOH, MeOH 2: PBr3, Py / diethyl ether 3: (i) EtMgBr, Et2O, (ii) /BRN= 1841586/, CuCl 4: (i) H2, Lindlar catalyst, EtOH, (ii) /BRN= 102415/, MeOH, Et2O View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 1015 - 1025
反应条件
1: PBr3, Py / diethyl ether 2: (i) EtMgBr, THF, (ii) /BRN= 1840948/, CuCl, (iii) TsOH, MeOH 3: PBr3, Py / diethyl ether 4: (i) EtMgBr, Et2O, (ii) /BRN= 1841586/, CuCl 5: (i) H2, Lindlar catalyst, EtOH, (ii) /BRN= 102415/, MeOH, Et2O View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 1015 - 1025
反应条件
1: PBr3, Py / diethyl ether 2: (i) EtMgBr, Et2O, (ii) /BRN= 1841586/, CuCl 3: (i) H2, Lindlar catalyst, EtOH, (ii) /BRN= 102415/, MeOH, Et2O View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 82, p. 1015 - 1025
反应条件
1: fish oil With potassium hydroxide; water in methanol T=55°C; 1.5 h; 2: methanol With sulfuric acid in water T=20 - 55°C; 1.5 h; Product distribution / selectivity;
参考文献
WO2008/86495 A1, ;
Page/Page column 18; 23-24; Sheet 1/5 ;
反应条件
1: (i) EtMgBr, THF, (ii) CuCN, (iii) /BRN= 1932459/ 2: (i) H2, quinoline, Pd-CaCO3, pentyl acetate, (ii) /BRN= 1098229/, aq. HCl View Scheme
参考文献
Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, , vol. 352, # 4 p. 542 - 548
