DHA 甲酯 Fame 22:6n-3 全顺-4,7,10,13,16,19-二十二碳六烯酸甲酯合成路线 （共 26 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=-80°C;
参考文献
Sandri; Viala
Journal of Organic Chemistry, 1995 , vol. 60, # 20 p. 6627 - 6630
反应条件
(i) H2, quinoline, Pd-CaCO3, pentyl acetate, (ii) /BRN= 1098229/, aq. HCl; Multistep reaction;
参考文献
Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, , vol. 352, # 4 p. 542 - 548
参考文献
Wright, Stephen W.; Kuo, Elaine Y.; Corey, E. J.
Journal of Organic Chemistry, 1987 , vol. 52, # 19 p. 4399 - 4401
反应条件
1: fish oil With potassium hydroxide; water in methanol T=55°C; 1.5 h; 2: methanol With sulfuric acid in water T=20 - 55°C; 1.5 h; Product distribution / selectivity;
参考文献
WO2008/86495 A1, ;
Page/Page column 18; 20-21; 27 ;
反应条件
1: pyridine, Ph3PBr2 / acetonitrile / 0 °C 2: acetonitrile / 24 h / Heating 3: 56 percent / NaN(SiMe3)2 / tetrahydrofuran / 1.) room temperature, 2.) -90 deg C 4: 100 percent / H+ / tetrahydrofuran 5: 86 percent / LiAlH4 / tetrahydrofuran / -70 °C 6: 94 percent / CBr4, Ph3P / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h 7: 95 percent / acetonitrile / Heating 8: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: acetonitrile / 24 h / Heating 2: 56 percent / NaN(SiMe3)2 / tetrahydrofuran / 1.) room temperature, 2.) -90 deg C 3: 100 percent / H+ / tetrahydrofuran 4: 86 percent / LiAlH4 / tetrahydrofuran / -70 °C 5: 94 percent / CBr4, Ph3P / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h 6: 95 percent / acetonitrile / Heating 7: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: 51 percent / NaN(SiMe3)2 / tetrahydrofuran / 1.) room temperature, 2.) -90 deg C 2: H+ / tetrahydrofuran 3: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: 94 percent / CBr4, Ph3P / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h 2: 95 percent / acetonitrile / Heating 3: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: 56 percent / NaN(SiMe3)2 / tetrahydrofuran / 1.) room temperature, 2.) -90 deg C 2: 100 percent / H+ / tetrahydrofuran 3: 86 percent / LiAlH4 / tetrahydrofuran / -70 °C 4: 94 percent / CBr4, Ph3P / CH2Cl2 / 1.) 0 deg C, 15 min, 2.) room temperature, 1 h 5: 95 percent / acetonitrile / Heating 6: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
反应条件
1: 51 percent / NaN(SiMe3)2 / tetrahydrofuran / 1.) room temperature, 2.) -90 deg C 2: H+ / tetrahydrofuran 3: 76 percent / NaN(SiMe3)2 / tetrahydrofuran / -80 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 20 p. 6627 - 6630
