(S)-2-((4-(三氟甲基)苯氧基)甲基)环氧乙烷合成路线 （共 3 条）
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=0 - 20°C;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2005/42478 A2, 2005 ;
Location in patent: Page/Page column 75 ;
WO 2005/042478 A2
反应条件
1: 4-(trifluoromethyl)phenol With potassium carbonate in butanone T=20°C; 0.166667 h; Inert atmosphereSchlenk technique; 2: (S)-(+)-epichlorohydrin in butanone T=90°C; 15 h; Inert atmosphereSchlenk technique;
参考文献
Park, Jung-Eun; Ji, Wan Keun; Jang, Jae Wan; Pae, Ae Nim; Choi, Keehyun; Choi, Ki Hang; Kang, Jahyo; Roh, Eun Joo
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1887 - 1890
反应条件
caesium carbonate in acetonitrile Reflux;
参考文献
Sun, Dianqing; Scherman, Michael S.; Jones, Victoria; Hurdle, Julian G.; Woolhiser, Lisa K.; Knudson, Susan E.; Lenaerts, Anne J.; Slayden, Richard A.; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3588 - 3594
