去甲托品酮盐酸盐合成路线

参考文献

VERTEX PHARMACEUTICALS, INCORPORATED
Patent: WO2006/23852 A2, 2006 ;
Location in patent: Page/Page column 84 ;
WO 2006/023852 A2

799283-74-2→25602-68-0去甲托品酮盐酸盐

参考文献

WO2006/58303 A2, ;

Page/Page column 70 ;
WO 2006/058303 A2

50893-53-31-氯乙基氯甲酸酯+532-24-1托品酮→25602-68-0去甲托品酮盐酸盐

参考文献

WO2004/100946 A1, ;

Page 77 ;
WO 2004/100946 A1

25602-68-0去甲托品酮盐酸盐→5632-84-8去甲托品酮

参考文献

AVENTIS PHARMACEUTICALS INC.
Patent: WO2004/100946 A1, 2004 ;
Location in patent: Page 58; 59 ;
WO 2004/100946 A1

25602-68-0去甲托品酮盐酸盐→185099-68-7(1R,5S)-3-(三氟甲基磺酰氧基)-8-氮杂双环[3.2.1]-2-辛烯-8-羧酸叔丁酯

参考文献

Lu, Zhijian; Tata, James R.; Cheng, Kang; Wei, Liente; Chan, Wanda W.-S.; Butler, Bridget; Schleim, Klaus D.; Jacks, Thomas M.; Hickey, Gerard; Patchett, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1817 - 1820

24424-99-5二碳酸二叔丁酯+25602-68-0去甲托品酮盐酸盐→185099-67-6N-叔丁氧羰基-去甲托品酮

参考文献

Roche Palo Alto LLC
Patent: US2009/318493 A1, 2009 ;
Location in patent: Page/Page column 41-42 ;
US 20090318493 A1

25602-68-0去甲托品酮盐酸盐+501-53-1氯甲酸苄酯→130753-13-8N-Cbz-去甲托品酮

参考文献

VERTEX PHARMACEUTICALS, INCORPORATED
Patent: WO2006/23852 A2, 2006 ;
Location in patent: Page/Page column 84 ;
WO 2006/023852 A2

25602-68-0去甲托品酮盐酸盐+108-24-7乙酸酐→56880-02-5(1R,5S)-8-乙酰基-8-氮杂双环[3.2.1]辛烷-3-酮

参考文献

SANOFI; BIALY, Laurent; LORENZ, Katrin; WIRTH, Klaus; STEINMEYER, Klaus; HESSLER, Gerhard; PERNERSTORFER, Josef; BRENDEL, Joachim
Patent: WO2013/37914 A1, 2013 ;
Location in patent: Page/Page column 64-65 ;