反应条件
1: 1.) butyl lithium, diisopropylamine / 1.) hexane/THF, 0 to -10 deg C, 10 min, 2.) THF, amb. temp., 1.5 h 2: 88 percent / bromine / CH2Cl2 / 1 h / 30 °C 3: 90 percent / aq. sodium hydroxide / Ambient temperature 4: 1.) sodium amide / 1.) toluene, reflux, 2 h, 2.) THF, 2 h 5: 84 percent / lithium aluminium hydride / tetrahydrofuran / 2 h / Heating 6: 92 percent / 12 M hydrochloric acid / 48 h / Heating View Scheme
参考文献
Bradley; Cavalla; Edington; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385
