甲基 4-氯-3,5-二硝基苯酸合成路线 （共 13 条）
反应条件
sulfuric acid in methanol
参考文献
The Upjohn Company
Patent: US3993679 A1, 1976 ;
反应条件
sulfuric acid 5 h; Heating / reflux;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS
Patent: US2007/32469 A1, 2007 ;
Location in patent: Page/Page column 37-38 ;
US 20070032469 A1
反应条件
sulfuric acid in methanol
参考文献
Budapesti Vegyimuvek
Patent: US4806151 A1, 1989 ;
反应条件
in diethyl ether T=0°C; 12 h;
参考文献
Benbow, John W.; Bernberg, Erin L.; Korda, Anna; Mead, Jan R.
Antimicrobial Agents and Chemotherapy, 1998 , vol. 42, # 2 p. 339 - 343
反应条件
1: 89.6 percent / HNO3, fuming sulfuric acid (30percent SO3) / 1.) 25-30 deg C, 2.) 85 deg C, 3.) 95 deg C, 4.5 h 2: 99.2 percent / conc. H2SO4 / 1.) 4 h, reflux, 2.) 25 deg C, 12-15 h View Scheme
参考文献
Ullmann
Justus Liebigs Annalen der Chemie, 1909 , vol. 366, p. 89
参考文献
Cheng, Cliff C.; Shipps Jr., Gerald W.; Yang, Zhiwei; Sun, Binyuan; Kawahata, Noriyuki; Soucy, Kyle A.; Soriano, Aileen; Orth, Peter; Xiao, Li; Mann, Paul; Black, Todd
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6507 - 6514
反应条件
N,N-diethylaniline; trichlorophosphate
参考文献
Borrows; Clayton; Hems
Journal of the Chemical Society, 1949 , p. Spl. 185, 188
参考文献
Ullmann; Sane
Chemische Berichte, 1911 , vol. 44, p. 3737
参考文献
Manka, Jason T.; Guo, Fengli; Huang, Jianping; Yin, Huiyong; Farrar, John M.; Sienkowska, Monika; Benin, Vladimir; Kaszynski, Piotr
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9574 - 9588
反应条件
1: pyridine 2: platinum; acetic acid / Hydrogenation.Behandeln des Reaktionsgemisches mit NaNO2 und H2SO4 und anschliessend mit wss. KI und Jod 3: platinum; diethylamine; ethyl acetate / Hydrogenation 4: KHCO3; aqueous methanol View Scheme
参考文献
Crowder et al.
Journal of the Chemical Society, 1958 , p. 2142,2146
