反应条件
1: 1a.) ethylmagnesium bromide, 1b.) cuprous chloride / 1a.) THF, reflux, 6 h, 1b.) 0 deg C, 15 min, 3.) reflux, 9 h
2: 66 percent / p-TsOH / methanol / 4 h / Heating
3: 92 percent / H2, quinoline / Lindlar's catalyst / hexane / Ambient temperature
4: 81 percent / triethylamine / CH2Cl2 / 0.5 h / -5 °C
5: 1.) Mg, iodine, 2.) HMPA / 1.) THF, 40-50 deg C, 1.5 h, 2.) 0-10 deg C, 30 min, 3.) RT, overnight
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Kumari, Sarla; Rani, Veena
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 769 - 770
