hydrogenchloride; hydrogen; palladium on activated charcoal in methanol 2.33333 h;

1: 44 percent / DCC, DMAP / CH2Cl2 / 96 h / 0 deg C to r.t. 2: 2.46 g / TFA / CH2Cl2 / 1) 3 min, 0 deg C, 2) 17 min, without cooling 3: 78 percent / pyridine / 1.87 h / 101 °C 4: H2, 0.1N aq.HCl / 10percent Pd-C / methanol / 2.33 h View Scheme

1: 44 percent / DCC, DMAP / CH2Cl2 / 96 h / 0 deg C to r.t. 2: 2.46 g / TFA / CH2Cl2 / 1) 3 min, 0 deg C, 2) 17 min, without cooling 3: 78 percent / pyridine / 1.87 h / 101 °C 4: H2, 0.1N aq.HCl / 10percent Pd-C / methanol / 2.33 h View Scheme

1: 78 percent / pyridine / 1.87 h / 101 °C 2: H2, 0.1N aq.HCl / 10percent Pd-C / methanol / 2.33 h View Scheme

1: 2.46 g / TFA / CH2Cl2 / 1) 3 min, 0 deg C, 2) 17 min, without cooling 2: 78 percent / pyridine / 1.87 h / 101 °C 3: H2, 0.1N aq.HCl / 10percent Pd-C / methanol / 2.33 h View Scheme