2-氨基-5-碘-3-硝基吡啶合成路线 （共 7 条）
反应条件
1: With sulfuric acid; acetic acid; periodic acid T=90°C; 0.25 h; 2: With iodine 1 h; Further stages.;
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
反应条件
sulfuric acid; acetic acid in water
参考文献
Research Triangle Institute
Patent: US6538010 B1, 2003 ;
反应条件
hydrogenchloride; iron in ethanol; hexane; water
参考文献
Research Triangle Institute
Patent: US6538010 B1, 2003 ;
反应条件
1.1: conc. HCl; NaNO2 1.2: 36 percent / CuCl 2.1: 92 percent / conc. HCl; Fe / ethanol; H2O / 0.33 h / 100 °C View Scheme
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
反应条件
hydrogenchloride; copper(l) chloride; sodium nitrite in water T=0 - 20°C; 12 h;
参考文献
ORION CORPORATION; LINNANEN, Tero; WOHLFAHRT, Gerd; NANDURI, Srinivas; UJJINAMATADA, Ravi; RAJAGOPALAN, Srinivasan; MUKHERJEE, Subhendu
Patent: WO2013/53983 A1, 2013 ;
Location in patent: Page/Page column 37 ;
反应条件
sodium nitrite; copper(I) bromide
参考文献
Research Triangle Institute
Patent: US6538010 B1, 2003 ;
反应条件
1.1: conc. HCl; NaNO2
1.2: 36 percent / CuCl
2.1: 89 percent / KF / dimethylformamide / 18 h / 45 °C
View Scheme
参考文献
Carroll, F. Ivy; Lee, Jeffrey R.; Navarro, Hernan A.; Ma, Wei; Brieaddy, Lawrence E.; Abraham, Philip; Damaj; Martin, Billy R.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4755 - 4761
