2-氨基-3-碘-5-硝基吡啶合成路线 （共 4 条）
反应条件
KIO3; sulfuric acid; potassium iodide T=100°C; 1 h;
参考文献
Pearson, Stuart E.; Nandan, Santosh
Synthesis, 2005 , # 15 art. no. P03505SS, p. 2503 - 2506
反应条件
1: 93 percent / CuI; Et3N / Pd(PPh3)2Cl2 / N,N-dimethyl-acetamide; tetrahydrofuran / 16 h / 20 °C 2: CuI / 1-methyl-pyrrolidin-2-one / 0.5 h / 190 °C / microwave irradiation 3: 80 percent / H2 / Pt/C / tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Pearson, Stuart E.; Nandan, Santosh
Synthesis, 2005 , # 15 art. no. P03505SS, p. 2503 - 2506
反应条件
1: 93 percent / CuI; Et3N / Pd(PPh3)2Cl2 / N,N-dimethyl-acetamide; tetrahydrofuran / 16 h / 20 °C 2: CuI / 1-methyl-pyrrolidin-2-one / 0.5 h / 190 °C / microwave irradiation View Scheme
参考文献
ADVINUS THERAPEUTICS LIMITED; BARAWKAR, Dinesh; BENDE, Tanushree; ZAHLER, Robert; BANDYOPADHYAY, Anish; SARANGTHEM, Robindro Singh; DOSHI, Jignesh; WAMAN, Yogesh; JADHAV, Rushikesh; SINGH, Umesh Prasad
Patent: WO2012/127506 A1, 2012 ;
WO 2012/127506 A1
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in N,N-dimethyl-formamide
参考文献
WO2010/62171 A2, ;
Page/Page column 148 ;
