4'-(咪唑-1-基)苯腈合成路线 （共 15 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=25°C; 2 h; Heating / reflux;
参考文献
WO2004/22561 A1, ;
Page 100-101 ;
WO 2004/022561 A1
参考文献
US2004/209878 A1, ;
US 20040209878 A1
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: With iodine in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Mano, Takashi; Stevens, Rodney W.; Ando, Kazuo; Nakao, Kazunari; Okumura, Yoshiyuki; Sakakibara, Minoru; Okumura, Takako; Tamura, Tetsuya; Miyamoto, Kimitaka
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3879 - 3887
反应条件
1,10-phenanthroline; di-tert-butyl peroxide; copper diacetate; sodium acetate; sodium t-butanolate in 1,2-dichloro-ethane
T=80°C; 6.03333 h; Inert atmosphereMolecular sieve;
参考文献
Chu, Lingling; Qing, Feng-Ling
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 1298 - 1304
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 35 percent / iodine / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 37 percent / cuprous iodide; potassium fluoride / dimethylformamide; 1-methyl-pyrrolidin-2-one / 41 h / 80 °C
View Scheme
参考文献
Mano, Takashi; Stevens, Rodney W.; Ando, Kazuo; Nakao, Kazunari; Okumura, Yoshiyuki; Sakakibara, Minoru; Okumura, Takako; Tamura, Tetsuya; Miyamoto, Kimitaka
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3879 - 3887
