(4S,5R)-5-乙炔基-4-异丙基-1,3-恶唑烷-2-酮合成路线 （共 3 条）
反应条件
sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=0°C; Cyclization; 1 h;
参考文献
Ohno, Hiroaki; Toda, Ayako; Takemoto, Yoshiji; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2949 - 2962
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / 0 °C 1.2: tetrahydrofuran; hexane / 2 h / -78 °C 2.1: 49 percent / NaH / dimethylformamide; tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Ohno, Hiroaki; Toda, Ayako; Takemoto, Yoshiji; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2949 - 2962
反应条件
1.1: oxalyl chloride; DMSO; diisopropylethylamine / CHCl3; hexane / 1.5 h / -78 - 0 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / 0 °C 2.2: tetrahydrofuran; hexane / 2 h / -78 °C 3.1: 49 percent / NaH / dimethylformamide; tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Ohno, Hiroaki; Toda, Ayako; Takemoto, Yoshiji; Fujii, Nobutaka; Ibuka, Toshiro
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2949 - 2962
