3,3-二甲基-1-(1-哌嗪基)-1-丁酮合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Bristol-Myers Squibb Co.
Patent: US6335324 B1, 2002 ;
Location in patent: Page column 64 ;
US 6335324 B1
反应条件
1: iPr2NEt; DMAP / CH2Cl2 2: TFA / CH2Cl2 View Scheme
参考文献
Sutton, James C.; Bolton, Scott A.; Hartl, Karen S.; Huang, Ming-Hsing; Jacobs, Glenn; Meng, Wei; Ogletree, Martin L.; Pi, Zulan; Schumacher, William A.; Seiler, Steven M.; Slusarchyk, William A.; Treuner, Uwe; Zahler, Robert; Zhao, Guohua; Bisacchi, Gregory S.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3229 - 3233
反应条件
[(1,3-bis[2,6-bis(diphenylmethyl)-4-methylphenyl]imidazole-2-ylidene)PdCl2(triethylamine)]; potassium tert-butylate in ethylene glycol dimethyl ether
T=20°C; Buchwald-Hartwig Coupling; 24 h; Sealed tube;
参考文献
Guest, Daniel; Chen, Ming-Tsz; Tizzard, Graham J.; Coles, Simon J.; Turner, Michael Lewis; Navarro, Oscar
European Journal of Inorganic Chemistry, 2014 , # 13 p. 2200 - 2203
