2-氨基-3-羧基苯甲酸甲酯合成路线 （共 6 条）
反应条件
sodium hydroxide; dihydrogen peroxide in water T=20°C; Oxidation; 0.25 h;
参考文献
Bu, Xianyong; Deady, Leslie W.
Synthetic Communications, 1999 , vol. 29, # 23 p. 4223 - 4233
反应条件
1: 94 percent / HCl / 3 h / Heating 2: 91 percent / NaOH; H2O2 / H2O / 0.25 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 29, # 23 p. 4223 - 4233
反应条件
in tetrahydrofuran 5 h; Reflux;
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
Location in patent: Page/Page column 91 ;
WO 2012/059442 A2
反应条件
methanol in tetrahydrofuran; diethyl ether
T=20°C;
参考文献
ABBOTT LABORATORIES; WOODS, Keith W.; LAI, Chunqiu; PENNING, Thomas D.; MIYASHIRO, Julie
Patent: WO2013/12681 A1, 2013 ;
Location in patent: Page/Page column 80 ;
反应条件
1: 3.5 h / Heating
2: NaBH4 / tetrahydrofuran; H2O / 0.17 h / 20 °C
3: 82 percent / MnO2 / CHCl3 / 20 °C
4: 0.49 g / H2SO4 / acetic acid / 4 h / Heating
5: Pd/C / diphenyl ether / Heating
View Scheme
参考文献
Bu, Xianyong; Deady, Leslie W.
Synthetic Communications, 1999 , vol. 29, # 23 p. 4223 - 4233
反应条件
in tetrahydrofuran
5 h; Reflux;
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
Location in patent: Page/Page column 91 ;
WO 2012/059442 A2
