3-氨基-2,2-二甲基丙酸甲酯合成路线 （共 14 条）
反应条件
hydrazine in methanol T=65°C; 5 h;
参考文献
NERVIANO MEDICAL SCIENCES S.r.l.
Patent: WO2007/68619 A1, 2007 ;
Location in patent: Page/Page column 91-92 ;
WO 2007/068619 A1
反应条件
hydrogenchloride T=20°C; 20 h;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogen; nickel in methanol P=2585.81 Torr; 24 h;
参考文献
Chen, Shaoqing
Patent: US2008/234255 A1, 2008 ;
Location in patent: Page/Page column 10 ;
反应条件
ammonia; hydrogen; mixture of 28percent NiO, 28percent CoO, 13percent CuO, 31percent ZrO2; hydrogenated in methanol T=100°C; P=150015 Torr; Product distribution / selectivity;
参考文献
BASF SE
Patent: US2008/306299 A1, 2008 ;
Location in patent: Page/Page column 4-5 ;
反应条件
potassium hydrogensulfate; I2 in toluene
参考文献
Merck and Co., Inc.
Patent: US5416099 A1, 1995 ;
反应条件
1: 84 percent / Me3SiOSO2CF3 / CH2Cl2 / Ambient temperature 2: 80 percent / MeOH / 24 h / Heating View Scheme
参考文献
Okano, Kohji; Morimoto, Toshiaki; Sekiya, Minoru
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 6 p. 2228 - 2234
反应条件
methanol 24 h; Heating;
参考文献
Okano, Kohji; Morimoto, Toshiaki; Sekiya, Minoru
Journal of the Chemical Society, Chemical Communications, 1984 , # 13 p. 883 - 884
反应条件
1: hydrogen bromide / water / 19 h / 100 °C 2: ammonia / 1,4-dioxane / 16 h / 60 °C / 2250.23 Torr / Autoclave 3: hydrogenchloride / 20 h / 20 °C View Scheme
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
反应条件
1.1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice 2.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube 2.2: 0.17 h / 0 - 20 °C 3.1: hydrogenchloride / 20 h / 20 °C View Scheme
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
反应条件
1.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube 1.2: 0.17 h / 0 - 20 °C 2.1: hydrogenchloride / 20 h / 20 °C View Scheme
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
