1: 3-methoxy-4-hydroxybenzylamine hydrochloride With sodium hydroxide in water; N,N-dimethyl-formamide
T=20°C; 1 h; Inert atmosphereCooling with ice;
2: n-heptanoic acid chloride in tetrahydrofuran; water; N,N-dimethyl-formamide
T=20°C; 18 h; Inert atmosphereCooling with ice;
参考文献
Barbero, Gerardo F.; Molinillo, Jose M. G.; Varela, Rosa M.; Palma, Miguel; MacIas, Francisco A.; Barroso, Carmelo G.
Journal of Agricultural and Food Chemistry, 2010 , vol. 58, # 6 p. 3342 - 3349
in diethyl ether; N,N-dimethyl-formamide
Ambient temperature;
参考文献
Janusz, John M.; Buckwalter, Brian L.; Young, Patricia A.; LaHann, Thomas R.; Farmer, Ralph W.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2595 - 2604
1: benzene / Hydrieren des Reaktionsprodukts an Palladium/Strontiumcarbonat in Butanon und Erwaermen der Reaktionsloesung
2: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Ames; Bowman
Journal of the Chemical Society, 1952 , p. 1057,1062