5-碘-1,2,3-三甲氧基苯合成路线 （共 37 条）
反应条件
tetrabutyl-ammonium chloride; potassium acetate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide Ambient temperatureor 80 deg C;
参考文献
Larock, Richard; Gong, William H.
Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 407 - 408
反应条件
tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate in N,N-dimethyl-formamide
T=50°C; Heck Reaction; 6.5 h; Schlenk techniqueInert atmosphere;
参考文献
Panther, Jesco; Roehrich, Adalbert; Mueller, Thomas J. J.
Arkivoc, 2012 , vol. 2012, # 3 p. 297 - 311
反应条件
1.1: copper(I) oxide; copper; potassium carbonate / diethylene glycol dimethyl ether / 5 h / Reflux
2.1: Eaton's reagent / 0.83 h / 80 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Pal, Chinmay; Kundu, Milan Kumar; Bandyopadhyay, Uday; Adhikari, Susanta
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 12 p. 3563 - 3567
反应条件
tetrabutyl-ammonium chloride; potassium acetate; palladium diacetate in N,N-dimethyl-formamide
T=80°C; 48 h; Yield given. Yields of byproduct given;
参考文献
Prashad, Mahavir; Tomesch, John C.; Wareing, James R.; Smith, Howard C.; Cheon, Seung Hoon
Tetrahedron Letters, 1989 , vol. 30, # 22 p. 2877 - 2880
反应条件
tetrakis(triphenylphosphine) palladium(0); triethylamine in 1,4-dioxane
T=80°C; Masuda borylation; 4 h; Inert atmosphere;
参考文献
Merkul, Eugen; Schaefer, Elisabeth; Mueller, Thomas J. J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3139 - 3141
反应条件
copper
T=150 - 190°C;
参考文献
Mayer,W. et al.
Chemische Berichte, 1960 , vol. 93, p. 2761 - 2776
反应条件
1.1: n-butyllithium / cyclohexane; tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -60 - 0 °C
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 16 h / 20 °C
3.1: AlCl3, aluminium chloride / dichloromethane / 0.25 h / 20 °C / Inert atmosphere
4.1: pyridine / 2 h / 20 °C
5.1: bromine / 1,2-dichloro-ethane / 0.17 h / 20 °C / Inert atmosphere
6.1: sodium hydrogencarbonate; water / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 2.08 h / 90 °C
View Scheme
参考文献
BIONOMICS LIMITED; FLYNN, Bernard Luke
Patent: WO2012/6686 A1, 2012 ;
反应条件
1: (i) Cu, (ii) NaOH, EtOH
2: CrO3 / Cu / quinoline / Heating
View Scheme
参考文献
Erdtman,H. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1151 - 1156
参考文献
Erdtman,H. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1151 - 1156
反应条件
zirconia-supported palladium; potassium carbonate in N,N-dimethyl-formamide
T=140°C; Ullmann type coupling; 5 h;
参考文献
Dumbre, Deepa K.; Wakharkar, Radhika D.; Choudhary, Vasant R.
Synthetic Communications, 2011 , vol. 41, # 2 p. 164 - 169
