5-碘-1,2,3-三甲氧基苯合成路线 （共 37 条）
反应条件
caesium tribromide in water; N,N-dimethyl-formamide T=80°C; 3 h; chemoselective reaction;
参考文献
Yao, Min-Liang; Kabalka, George W.; Blevins, David W.; Reddy, Marepally Srinivasa; Yong, Li
Tetrahedron, 2012 , vol. 68, # 19 p. 3738 - 3743
反应条件
1: With hydrogenchloride; water; sodium nitrite T=5°C; 2: With potassium iodide in water T=0 - 20°C;
参考文献
Barbosa, Euzebio G.; Bega, Luis A.S.; Beatriz, Adilson; Sarkar, Taradas; Hamel, Ernest; do Amaral, Marcos S.; de Lima, Denis Pires
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2685 - 2688
反应条件
NISacc T=20°C; Ionic liquidDarkness;
参考文献
Bailey, Lindsey; Handy, Scott T.
Tetrahedron Letters, 2011 , vol. 52, # 18 p. 2413 - 2414
反应条件
1: H2 / Pd-C / ethanol 2: (i) NaNO2, aq. H2SO4, (ii) aq. KI View Scheme
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 17, p. 1151 - 1156
反应条件
1.1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C 1.2: 0.5 h 2.1: Cu(OTf)2; potassium fluoride; 18-crown-6 ether / N,N-dimethyl-formamide / 18 h / 60 °C View Scheme
参考文献
Organic Letters, , vol. 15, # 19 p. 5134 - 5137
反应条件
diiodomethane; 2,2'-azo-bisisobutyronitrile; Fonderma in toluene 0.583333 h; Heating; Yield given;
参考文献
Tetrahedron, , vol. 43, # 19 p. 4321 - 4328
反应条件
1: thionyl chloride 2: N-hydroxypyridine-2-thione sodium salt, AIBN, CH2I2 / toluene / 0.58 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 19 p. 4321 - 4328
反应条件
AlCl3, aluminium chloride in dichloromethane T=60°C; 6 h;
参考文献
KOWA CO., LTD.
Patent: US2003/232992 A1, 2003 ;
Location in patent: Page 6 ;
反应条件
dichloro(cycloocta-1,5-diene)palladium(II); N,N-dicyclohexylmethylamine; potassium formiate; tetra-(n-butyl)ammonium iodide; PCy3∙HBF4; bis(dibenzylideneacetone)-palladium(0); [(t-Bu)3PH]BF4 in acetonitrile T=80°C; 18 h; Sealed tubeGloveboxInert atmosphere;
参考文献
Korsager, Signe; Taaning, Rolf H.; Lindhardt, Anders T.; Skrydstrup, Troels
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 6112 - 6120
反应条件
1: copper-powder / 270 °C 2: aqueous HBr View Scheme
参考文献
Critchlow et al.
Journal of the Chemical Society, 1951 , p. 1318,1323
