5-甲氧基-1-甲基-1H-吲哚合成路线 （共 18 条）
反应条件
1: 5-Methoxy-1H-indole With tri[2-(2-methoxyethoxy)ethyl]amine; potassium tert-butylate in benzene T=20°C; 1 h; 2: methyl iodide in benzene T=20°C; 0.5 h;
参考文献
Diana, Patrizia; Carbone, Anna; Barraja, Paola; Kelter, Gerhard; Fiebig, Heinz-Herbert; Cirrincione, Girolamo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4524 - 4529
反应条件
1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl-formamide T=94 - 95°C; 10 h;
参考文献
Dell, Steven; Lozanov, Mario Emilov; Shieh, Wen-Chung
Patent: US2004/59131 A1, 2004 ;
Location in patent: Page 6 ;
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US6326501 B1, 2001 ;
反应条件
p-benozquinone; lithium chloride; dichloro bis(acetonitrile) palladium(II) in tetrahydrofuran 18 h; Heating;
参考文献
Yamaguchi, Masahiko; Arisawa, Mieko; Hirama, Masahiro
Chemical Communications, 1998 , # 13 p. 1399 - 1400
反应条件
1: 5-Methoxy-1H-indole With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; 1 h; Inert atmosphere; 2: methy halide T=0 - 20°C; 24 h;
参考文献
Fraile, Jose M.; Le Jeune, Karel; Mayoral, Jose A.; Ravasio, Nicoletta; Zaccheria, Federica
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 26 p. 4327 - 4332
反应条件
1: 1.) SnCl4, Bu3N, 2.) KOH, H2O / 1.) chlorobenzene, -50 deg C to 80 deg C, 2.) chlorobenzene, THF, reflux 2: 85 percent / quinone, LiCl / PdCl2(MeCN)2 / tetrahydrofuran / 18 h / Heating View Scheme
参考文献
Yamaguchi, Masahiko; Arisawa, Mieko; Hirama, Masahiro
Chemical Communications, 1998 , # 13 p. 1399 - 1400
反应条件
1: 93 percent / KOH, H2O / methanol / 0.17 h / Heating 2: 85 percent / quinone, LiCl / PdCl2(MeCN)2 / tetrahydrofuran / 18 h / Heating View Scheme
参考文献
Yamaguchi, Masahiko; Arisawa, Mieko; Hirama, Masahiro
Chemical Communications, 1998 , # 13 p. 1399 - 1400
反应条件
in benzene 0.5 h; Heating;
参考文献
Baudin, Jean-Bernard; Commenil, Marie-Gabrielle; Julia, Sylvestre A.; Lorne, Robert; Mauclaire, Laurent
Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 4 p. 329 - 350
参考文献
Cook et al.
Journal of the Chemical Society, 1951 , p. 1203,1206
反应条件
1: aqueous acetic acid / Erwaermen des Reaktionsprodukts mit wss.-aethanol. H2SO4 2: 200 °C View Scheme
参考文献
Cook et al.
Journal of the Chemical Society, 1951 , p. 1203,1206
