2-氯-5-硝基苯甲酸合成路线 （共 155 条）
反应条件
1: SOCl2 / 3 h / Heating
2: 81 percent / NaHCO3 / CH2Cl2; H2O / Ambient temperature
View Scheme
参考文献
Balkrishna, Shah Jaimin; Kumar, Sangit
Synthesis, 2012 , vol. 44, # 9 p. 1417 - 1426
反应条件
1: ethanolic KOH-solution; copper-powder
2: concentrated sulfuric acid
3: nitric acid; sulfuric acid
4: acetic acid; tin (II)-chloride; hydrogen chloride
5: acetic acid
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参考文献
Amstutz; Neumoyer
Journal of the American Chemical Society, 1947 , vol. 69, p. 1925,1928
反应条件
1: SOCl2 / 3 h / Heating
2: acetone / Ambient temperature
View Scheme
参考文献
Dey; Doraiswami
Journal of the Indian Chemical Society, 1933 , vol. 10, p. 353,357
反应条件
1: 85 percent / PCl5 / chlorobenzene / 1.) RT, 24 h, 2.) 50 deg C, 1 h
2: 83 percent / AlCl3 / 24 h / Ambient temperature
3: 86 percent / K2CO3 / ethanol / 2 h / Heating
4: 65 percent / Fe, 1 N HCl / ethanol / 15 h / Heating
View Scheme
参考文献
Bellamy; Chazan; Dodey; Dutartre; Ou; Pascal; Robin
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1545 - 1552
反应条件
1: 93.1 percent / phosphorus pentachloride / benzene / 3 h / Heating
2: 85.4 percent / aluminium chloride / 1 h / Heating
3: 56.1 percent / KOH / H2O / 5 h / 150 - 160 °C
4: 64.4 percent / 40percent aq. KOH, hydroxylamine hydrochloride / 5 h
View Scheme
参考文献
Hayashi, Ikuo; Ogihara, Keizo; Shimizu, Kiyoshi
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 8 p. 2432 - 2437
反应条件
1-methyl-pyrrolidin-2-one in N-ethyl-N,N-diisopropylamine
参考文献
Development Finance Corporation of New Zealand
Patent: US4590277 A1, 1986 ;
参考文献
Rewcastle, Gordon W.; Denny, William A.
Synthesis, 1985 , # 2 p. 220 - 222
反应条件
1: 95 percent / H2 gas / platinic oxide / ethanol / Ambient temperature
2: 1.) NaNO2, 2N HCl; 2.) cuprous cyanide / 1.) water, 0 deg C, 35 min; 2.) water, 60 deg C, 40 min
View Scheme
参考文献
Hino; Nakamura; Kato; Irie; Nagai; Uno
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 9 p. 3462 - 3467
反应条件
1: SOCl2 / 1.5 h / Heating
2: 2.) water, concd. H2SO4 / 1.) ether, THF, ethanol, reflux, 2 h; 2.) acetic acid, reflux, 4 h
3: 65 percent / dimethylsulfoxide / 6 h / 95 °C
4: 27 percent / Fe-powder, concd. HCl / ethanol; H2O / 4 h / Heating
5: 86 percent / 6N HCl / 0.25 h / Heating
View Scheme
参考文献
Pieper; Seydel; Kruger; Noll; Keck; Wiese
Arzneimittel-Forschung/Drug Research, 1989 , vol. 39, # 9 p. 1073 - 1080
反应条件
1: aq. KOH / Cu
2: NaBH4 / tetrahydrofuran
3: SOCl2 / benzene
4: (i) DMF, (ii) aq. H2SO4, AcOH
View Scheme
参考文献
Sindelar,K. et al.
Collection of Czechoslovak Chemical Communications, 1975 , vol. 40, p. 2650 - 2666
