5-氨基-5-脱氧胸腺嘧啶脱氧核苷合成路线 （共 9 条）
反应条件
phosphate buffer; thymidine phosphorylase pH=6.8; 24 h;
参考文献
Chi, Xiuling; Baba, Satoshi; Tibrewal, Nidhi; Funabashi, Masanori; Nonaka, Koichi; Van Lanen, Steven G.
MedChemComm, 2013 , vol. 4, # 1 p. 239 - 243
反应条件
HEPES buffer; N-hexadecyl-N,N,N-trimethylammonium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in hexane; pentan-1-ol T=25°C; variation of condition; Product distribution;
参考文献
Helvetica Chimica Acta, , vol. 76, # 3 p. 1341 - 1351
反应条件
1: pyridine 2: DMAP; pyridine / 12 h 3: DCC; pyridine / dioxane View Scheme
参考文献
Reddy, Putta Mallikarjuna; Bruice, Thomas C.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1281 - 1285
反应条件
hydrogen; palladium on activated charcoal in methanol
13 h;
参考文献
Wako Pure Chemical Industries, Ltd.
Patent: US2008/64868 A1, 2008 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
ethylenediamine in tetrahydrofuran
4 h;
参考文献
Tetzlaff, Charles N.; Schwope, Ina; Bleczinski, Colleen F.; Steinberg, Joshua A.; Richert, Clemens
Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4215 - 4218
反应条件
1: LiN3 / dimethylformamide / 4 h / 90 °C
2: H2 / Pd/C / ethanol / 6 h / 20 °C
View Scheme
参考文献
Challa, Hemavathi; Bruice, Thomas C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1475 - 1481
反应条件
1: 97 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran
2: ethylenediamine / tetrahydrofuran
View Scheme
参考文献
Charles; Arya, Dev P.
Journal of Carbohydrate Chemistry, 2005 , vol. 24, # 2 p. 145 - 160
反应条件
1: 88 percent / NaN3 / dimethylformamide / 6 h / 80 °C
2: 6 h / Ambient temperature
3: H2O
View Scheme
参考文献
Druillennec, Sabine; Meudal, Herve; Roques, Bernard P.; Fournie-Zaluski, Marie-Claude
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 627 - 632
反应条件
HEPES buffer; water; sodium chloride
T=37°C; influence of pH on velocity constant;
参考文献
Thomson, James B.; Patel, Bhisma K.; Jimenez, Victor; Eckart, Klaus; Eckstein, Fritz
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6273 - 6281
