3,5-二甲基异噁唑-4-羧酸合成路线 （共 19 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 277, p. 174
反应条件
potassium dichromate; sulfuric acid
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 2736,2743; engl. Ausg. S. 2762, 2768
反应条件
1: ZnCl2; HCl; 1,2-dichloro-ethane 2: lead (II)-oxide-hydrate 3: K2cr2O7; aqueous H2SO4 View Scheme
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 2736,2743; engl. Ausg. S. 2762, 2768
反应条件
potassium dichromate; sulfuric acid
参考文献
Zhurnal Obshchei Khimii, , vol. 28, p. 2736,2743; engl. Ausg. S. 2762, 2768
反应条件
(i) NBS, (PhCO)2O2, CCl4, (ii) CrO3, H2SO4; Multistep reaction;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 33, p. 1192 - 1196,1170 - 1173
反应条件
1: SOCl2 2: diethyl ether View Scheme
参考文献
Hoffmann-La Roche
Patent: DE634286 , 1935 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 502
Full Text Show Details
Hoffmann-La Roche
Patent: CH185280 , 1936 ;
参考文献
Natale, N. R.; McKenna, John I.; Niou, Chorng-Shyr; Borth, Mark; Hope, Hakon
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5660 - 5666
反应条件
1: 68 percent / lithium aluminum hydride / tetrahydrofuran / 1.) 0 deg C, 2.) room temperature 2: 53 percent / potassium dichromate, Adogen-464 / ethyl acetate / 18 h / Heating View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
1: thionyl chloride / 70 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C 4: tetrahydrofuran; diethyl ether / 1.67 h / 0 - 20 °C 5: pyridinium chlorochromate / dichloromethane / 1 h / 0 - 20 °C View Scheme
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
WO 2013/019682 A1
反应条件
copper(l) iodide; thionyl chloride 1. 25 deg C, overnight 2. ether, -78 deg C -> 0 deg C -> -78 deg C 3. a) -78 deg C, 20 min b) -10 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Sauers, R. R.; Hadel, L. M.; Scimone, A. A.; Stevenson, T. A.
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4011 - 4019
