4-甲基-1,3-噁唑-5-甲酸合成路线 （共 9 条）
反应条件
1: T=20 - 120°C; 2: With sodium hydroxide; water T=20°C; 4 h; 3: With hydrogenchloride; water pH=2;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/22933 A1, 2007 ;
Location in patent: Page/Page column 31-32 ;
WO 2007/022933 A1
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane T=0 - 20°C; Hydrolysis; 5 h;
参考文献
Ray, Sibdas; Ghosh, Sukla
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 8 p. 986 - 988
反应条件
formic acid; ammonium formate Behandeln des Reaktionsprodukts mit wss. NaOH;
参考文献
Journal of the Chemical Society, , p. 93,95
反应条件
barium carbonate Behandeln des Reaktionsprodukts mit aethanol. NaOH;
参考文献
Yakugaku Zasshi, , vol. 76, p. 307
Chem.Abstr., , p. 13874
参考文献
Cornforth; Cornforth
Journal of the Chemical Society, 1953 , p. 93,95
反应条件
1: 68 percent / SOCl2 / 1) 90-100 deg C, 3 h, 2) 110-120 deg C, 5 h 2: 93 percent / diethyl ether / 1) ice-bath temperature, 1 h, 2) up to r. t., overnight 3: 55 percent / 0.5 N aq. H2SO4 / 3 h View Scheme
参考文献
Sen, A. K.; Sengupta, D. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 535 - 538
反应条件
water; caesium carbonate; Pd0(tris(tert-butyl)phosphine)2 in N,N-dimethyl-formamide T=190°C; 0.133333 h; microwave irradiation;
参考文献
Forgione, Pat; Brochu, Marie-Christine; St.-Onge, Miguel; Thesen, Kris H.; Bailey, Murray D.; Bilodeau, Francois
Journal of the American Chemical Society, 2006 , vol. 128, # 35 p. 11350 - 11351
反应条件
oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=20°C; 9 h;
参考文献
Jacobi, Peter A.
Patent: US2009/143346 A1, 2009 ;
Location in patent: Page/Page column 8 ;
反应条件
1: thionyl chloride / 4 h / Heating
2: toluene; pyridine / 0.5 h / Ambient temperature
3: 32 percent / xylene / 120 h / 140 °C
View Scheme
参考文献
Shimada, Sadakatsu; Tojo, Toshiaki
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4247 - 4258
