2-[1-(4-氯苯甲酰基)-5-羟基-2-甲基吲哚-3-基]乙酸合成路线 （共 7 条）
反应条件
boron tribromide in dichloromethane T=20°C;
参考文献
NITROMED, INC.
Patent: WO2006/99416 A1, 2006 ;
Location in patent: Page/Page column 72 ;
WO 2006/099416 A1
反应条件
glucose-6-phosphate dehydrogenase; G-6-P; NADP; magnesium chloride in aq. phosphate buffer T=37°C; pH=7.4; 3 h; Enzymatic reaction; TimeReagent/catalyst;
参考文献
Xie, Gang; Zhou, Dingying; Cheng, Ka-Wing; Wong, Chi C.; Rigas, Basil
Biochemical Pharmacology, 2013 , vol. 85, # 8 p. 1195 - 1202
反应条件
glucose-6-phosphate dehydrogenase; G-6-P; NADP; magnesium chloride in aq. phosphate buffer T=37°C; pH=7.4; 0.333333 h; Enzymatic reaction; TimeReagent/catalyst;
参考文献
Xie, Gang; Zhou, Dingying; Cheng, Ka-Wing; Wong, Chi C.; Rigas, Basil
Biochemical Pharmacology, 2013 , vol. 85, # 8 p. 1195 - 1202
反应条件
trifluoroacetic acid 1 h;
参考文献
Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728
反应条件
1.1: 62 percent / AcONa / acetic acid / 2 h / Heating 2.1: tBuOK / tetrahydrofuran / 0.33 h 2.2: 100 percent / tetrahydrofuran / 11 h 3.1: H2; AcOH / Pd/C / ethyl acetate / 3 h / 2888.19 Torr 4.1: 88 percent / CF3COOH / 1 h View Scheme
参考文献
Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728
反应条件
1.1: 62 percent / AcONa / acetic acid / 2 h / Heating 2.1: tBuOK / tetrahydrofuran / 0.33 h 2.2: 100 percent / tetrahydrofuran / 11 h 3.1: H2; AcOH / Pd/C / ethyl acetate / 3 h / 2888.19 Torr 4.1: 88 percent / CF3COOH / 1 h View Scheme
参考文献
Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728
反应条件
1.1: tBuOK / tetrahydrofuran / 0.33 h 1.2: 100 percent / tetrahydrofuran / 11 h 2.1: H2; AcOH / Pd/C / ethyl acetate / 3 h / 2888.19 Torr 3.1: 88 percent / CF3COOH / 1 h View Scheme
参考文献
Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728
