4-(2-甲基-1,3-噻唑-4-基)苯胺合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate P=3000.3 Torr; 5 h;
参考文献
Dong Wha Pharm. Co., Ltd.
Patent: EP2394993 A2, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
hydrogenchloride in ethanol; water Reflux;
参考文献
Yurttas, Leyla; Oezkay, Yusuf; Akalin-Ciftci, Guelsen; Ulusoylar-Yildirim, Safak
Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 2 p. 175 - 184
反应条件
1: ethanol / 16 h / 60 - 65 °C 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 5 h / 3000.3 Torr View Scheme
参考文献
EP2394993 A2, ;
US2011/306606 A1, ;
US 20110306606 A1
反应条件
1: copper(ll) bromide / ethyl acetate / 8 h / 60 - 65 °C 2: ethanol / 16 h / 60 - 65 °C 3: hydrogen / palladium 10 on activated carbon / ethyl acetate / 5 h / 3000.3 Torr View Scheme
参考文献
EP2394993 A2, ;
US2011/306606 A1, ;
US 20110306606 A1
反应条件
1: ethanol 2: aq. HCl / ethanol View Scheme
参考文献
Zhurnal Organicheskoi Khimii, , vol. 13, p. 1980 - 1987,1839 - 1845
反应条件
1: HNO3, H2SO4 / 5 °C 2: Fe, HCO2H, AcOH / aq. ethanol / Heating View Scheme
参考文献
Journal of pharmaceutical sciences, , vol. 58, # 7 p. 852 - 857
反应条件
1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C 2: bromine; hydrogen bromide; acetic acid 3: ethanol / 48 h / 20 °C 4: hydrogenchloride / ethanol; water / |Reflux View Scheme
参考文献
Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 28, # 5 p. 1040 - 1047
反应条件
1: bromine; hydrogen bromide; acetic acid 2: ethanol / 48 h / 20 °C 3: hydrogenchloride / ethanol; water / |Reflux View Scheme
参考文献
Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 28, # 5 p. 1040 - 1047
参考文献
Journal of pharmaceutical sciences, , vol. 58, # 7 p. 852 - 857
反应条件
(i) EtOH, (ii) aq. HCl; Multistep reaction;
参考文献
Journal of the Indian Chemical Society, , vol. 56, # 12 p. 1243 - 1245
