5-甲基-1H-吡唑-3-羧酸甲酯合成路线 （共 12 条）
反应条件
hydrazine hydrate in methanol T=0 - 20°C; 1 h;
参考文献
Shi, Xiao-Ming; Tang, Rui-Ren; Gu, Guo-Liang; Huang, Ke-long
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2009 , vol. 72, # 1 p. 198 - 203
反应条件
in acetone T=90°C; 0.333333 h;
参考文献
Journal of Organic Chemistry, , vol. 59, # 2 p. 455 - 462
反应条件
in methanol-d4 6 h; Ambient temperatureIrradiation;
参考文献
Journal of Organic Chemistry, , vol. 59, # 2 p. 455 - 462
反应条件
hydrogenchloride; methanol
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2>126, p. 150,165
Chemische Berichte, , vol. 61, p. 2405
反应条件
1: aqueous ethanol 2: HCl; methanol View Scheme
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2>126, p. 150,165
Chemische Berichte, , vol. 61, p. 2405
反应条件
in acetone T=90°C; other solvents, temperature; Rate constantMechanism;
参考文献
Journal of Organic Chemistry, , vol. 59, # 2 p. 455 - 462
反应条件
1: in N,N-dimethyl-formamide T=80 - 90°C; 21 h; 2: With ammonia in water; N,N-dimethyl-formamide T=0°C; 21 h;
参考文献
PFIZER INC.
Patent: WO2006/48761 A2, 2006 ;
Location in patent: Page/Page column 33 ;
WO 2006/048761 A2
参考文献
v. Auwers; Breyhan
Journal fuer Praktische Chemie (Leipzig), 1935 , vol. <2> 143, p. 259,273
反应条件
1: 1.) t-BuOK / 1.) THF, , reflux, 1 h, 2.) THF, reflux, overnight 2: 65 percent / LiAlH4 / tetrahydrofuran / 6 h / Heating 3: 75 percent / SOCl2 / Ambient temperature View Scheme
参考文献
Chabert-Couchouron, Nathalie; Reibel, Corine; Marzin, Claude; Tarrago, Georges
Anales de Quimica, 1996 , vol. 92, # 2 p. 70 - 78
反应条件
triethylamine in acetonitrile
5 h; Heating;
参考文献
Shroff, James R.; Bandurco, Victor; Desai, Rohit; Kobrin, Sidney; Cervoni, Peter
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1521 - 1525
