4-氯-3-氯磺酰基苯甲酸合成路线 （共 14 条）
反应条件
chlorosulfonic acid T=140°C; 2 h;
参考文献
Weichert, Andreas; Faber, Sabine; Jansen, Hans W.; Scholz, Wolfgang; Lang, Hans J.
Arzneimittel-Forschung/Drug Research, 1997 , vol. 47, # 11 p. 1204 - 1207
反应条件
sulfur trioxide T=110 - 160°C;
反应条件
chlorosulphuric acid 1) 120 deg C, 1 h 2) 150 deg C, 2 h; Yield given;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 7 p. 2010 - 2017
反应条件
T=150°C; 5 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 11 p. 3756 - 3767
反应条件
1: 94 percent / SOCl2 / benzene / 8 h / Heating 2: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating 3: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr 4: 93 percent / 10percent NaOH / 1 h View Scheme
参考文献
Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017
反应条件
1: 94 percent / SOCl2 / benzene / 8 h / Heating 2: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating 3: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr 4: 82 percent / 25 aq. NH3 / H2O / 2 h View Scheme
参考文献
Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017
反应条件
1: 94 percent / SOCl2 / benzene / 8 h / Heating 2: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating 3: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr 4: 82 percent / 25 aq. NH3 / H2O / 2 h 5: 71 percent / SOCl2 / chlorobenzene / 3 h / Heating View Scheme
参考文献
Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017
反应条件
1: 94 percent / SOCl2 / benzene / 8 h / Heating 2: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating 3: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr 4: 93 percent / 10percent NaOH / 1 h 5: 81 percent / SOCl2 / benzene / Heating View Scheme
参考文献
Suzuki, Hiroshi; Yazawa, Naoto; Yoshida, Yasuo; Furusawa, Osamu; Kimura, Yoshikazu
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 7 p. 2010 - 2017
反应条件
1: 94 percent / SOCl2 / benzene / 8 h / Heating 2: 71 percent / KF, Ph4PBr / acetonitrile / 16 h / Heating 3: 45 percent / KF, PPh4Br / tetrahydrothiophene 1,1-dioxide; toluene / 210 °C / 270 Torr 4: 82 percent / 25 aq. NH3 / H2O / 2 h 5: 65 percent / Br2, aq. KOH / H2O / 1 h / 0 - 88 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 7 p. 2010 - 2017
反应条件
sulfuric acid; nitric acid
参考文献
Merck and Co., Inc.
Patent: US3953476 A1, 1976 ;
