3-环丙基-3-羰基-丙酸乙酯合成路线 （共 26 条）
反应条件
zinc(II) chloride in benzene 4 h; Heatingalso in refluxing toluene; acid additives and their quantity varied; time; Product distribution;
参考文献
Heterocycles, , vol. 50, # 1 p. 479 - 483
反应条件
(i) NH2OH*HCl, aq. NaOH, (ii) aq. HCl; Multistep reaction;
参考文献
Jacquier,R. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 2685 - 2690
反应条件
1: 1,4-dioxane / 4 h / 20 - 100 °C 2: sodium acetate / N,N-dimethyl-formamide / 2 h / 20 - 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10652 - 10661
反应条件
1: 62 percent / LiAlH4 / diethyl ether
2: 86 percent / bromine, triphenylphosphine / acetonitrile / 0.17 h
3: 55-60 percent NaH / dimethylsulfoxide; diethyl ether / 0.75 h
4: 30 percent / conc. H2SO4 / H2O; tetrahydrothiophene 1,1-dioxide / 0.17 h
View Scheme
参考文献
Hanack,M.; Auchter,G.
Journal of the American Chemical Society, 1985 , vol. 107, p. 5238
反应条件
1: 69 percent / NaBH4 / ethanol
2: 75 percent / HBr, ZnBr2
View Scheme
参考文献
Wolf,H. et al.
Tetrahedron Letters, 1979 , p. 2339 - 2342
反应条件
1: 1,4-dioxane / 7 h / 100 °C
2: sodium methylate / methanol / 4 h / 80 °C
View Scheme
参考文献
Scott, James S.; Gill, Adrian L.; Godfrey, Linda; Groombridge, Sam D.; Rees, Amanda; Revill, John; Schofield, Paul; Soerme, Pernilla; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6756 - 6761
