hydrogenchloride; sodium ethanolate 1.) ethanol, reflux, overnight; Yield given. Multistep reaction;

in ethanol Reflux;

unter vermindertem Druck;

暂无反应条件数据

1: 1.) NaOEt, 2.) KOH / 1.) THF, -40 deg C, 2.) ethanol, 25 deg C 2: 74 percent / KOH / ethanol / 25 °C View Scheme

1: 72 percent / aq. NaNO2 / acetic acid / 4 h / Ambient temperature 2: 60 percent / H2, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature 3: 24 percent / Et3N / ethanol 4: 62 percent / K2CO3 / dimethylformamide / 16 h / Ambient temperature 5: 98 percent / trifluoroacetic acid / CH2Cl2 / 16 h / Ambient temperature 6: 100 percent / Et3N / CH2Cl2 / 0.75 h / -70 °C 7: 95 percent / aq. NaOH / methanol / 3 h / 50 °C 8: 1.) CDI, 2.) NH3 / 1.) THF, RT, 3 h, 2.) THF, EtOH, a.) RT, 16 h, b.) reflux, 4 h View Scheme

potassium carbonate in acetone T=20°C; 24 h;

hydrogenchloride; potassium hydroxide; sodium ethanolate 1.) THF, -40 deg C, 0.5 h, 2.) ethanol, 15 min, 3.) heating, 1 h; Yield given. Multistep reaction;

methanesulfonic acid in benzene 10 h; Heating;

methanesulfonic acid in benzene 10 h; Heatingazeotropic dehydration;