N-叔丁基氧羰基-L-组氨酸甲酯合成路线 （共 12 条）
反应条件
1: 25 percent / Et3N, Br2 / CHCl3 / 0 deg C to room temperature 2: 73 percent / NaOH / methanol / 1 h 3: 1.) DCC, Et3N, 2.) Pd-C, H2, Rh-C, Amberlite IR 45 (acetate form) / 1.) DMF, 0 deg C, 4 h, 2.) aq. AcOH, 2 h View Scheme
参考文献
Brown, Tom; Jones, John H.; Richards, John D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 7 p. 1553 - 1562
反应条件
1: 25 percent / Et3N, Br2 / CHCl3 / 0 deg C to room temperature 2: 73 percent / NaOH / methanol / 1 h 3: 70 percent / 1-hydroxybenzotriazole, DCC, Et3N / dimethylformamide / 0 deg C to room temperature 4: TFA / 0.5 h / Ambient temperature 5: 79 percent / Et3N / dimethylformamide / 16 h 6: 76 percent / Amberlite IR 45 (acetate form), H2 / Rh-C, Pd-C / aq. acetic acid / 6 h View Scheme
参考文献
Brown, Tom; Jones, John H.; Richards, John D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 7 p. 1553 - 1562
