3-氧代-2-戊基-1-环戊烯-1-乙酸甲酯合成路线 （共 22 条）
反应条件
1: 1) NaH / 1) DMF, 2) 50 deg C
2: t-BuOK / 2-methyl-propan-2-ol
3: p-TsOH / benzene
4: 1) Et4NOTs, 2) HCl / 1) isopropanol, 65 deg C, electroreduction (Sn-cathode), 2) r. t., 12 h
View Scheme
参考文献
Shono, Tatsuya; Kise, Naoki; Fujimoto, Taku; Tominaga, Naoto; Morita, Hiroshi
Journal of Organic Chemistry, 1992 , vol. 57, # 28 p. 7175 - 7187
反应条件
1: (i) NaH, (ii) /BRN= 1730981/
2: HCl / acetic acid
3: TsOH
4: (i) Br2, CaCO3, (ii) LiBr, Li2CO3
5: (i) Li<N(SiMe3)2>, (ii) /BRN= 1857975/
6: CrO3, H2SO4
View Scheme
参考文献
Ravid; Ikan
Journal of Organic Chemistry, 1974 , vol. 39, # 17 p. 2637 - 2639
反应条件
1: (i) Li<N(SiMe3)2>, (ii) /BRN= 1857975/
2: CrO3, H2SO4
View Scheme
参考文献
Ravid; Ikan
Journal of Organic Chemistry, 1974 , vol. 39, # 17 p. 2637 - 2639
反应条件
1: HCl / acetic acid
2: TsOH
3: (i) Br2, CaCO3, (ii) LiBr, Li2CO3
4: (i) Li<N(SiMe3)2>, (ii) /BRN= 1857975/
5: CrO3, H2SO4
View Scheme
参考文献
Ravid; Ikan
Journal of Organic Chemistry, 1974 , vol. 39, # 17 p. 2637 - 2639
反应条件
1: (i) NaH, (ii) /BRN= 1730981/
2: HCl / acetic acid
3: TsOH
4: (i) Br2, CaCO3, (ii) LiBr, Li2CO3
5: (i) Li<N(SiMe3)2>, (ii) /BRN= 1857975/
6: CrO3, H2SO4
View Scheme
参考文献
Ravid; Ikan
Journal of Organic Chemistry, 1974 , vol. 39, # 17 p. 2637 - 2639
反应条件
1: With sodium methylate in methanol
2: With sodium chloride in 1-methyl-pyrrolidin-2-one
T=180°C;
参考文献
Winter, Beat; Chapuis, Christian; Brauchli, Robert; De Saint Laumer, Jean-Yves
Helvetica Chimica Acta, 2013 , vol. 96, # 2 p. 246 - 258
反应条件
1.1: dihydrogen peroxide; potassium hydroxide; potassium carbonate / methanol
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C
2.2: 0.5 h / -78 °C
3.1: boron trifluoride diethyl etherate / toluene / 40 h / 0 - 20 °C
View Scheme
参考文献
Winter, Beat; Chapuis, Christian; Brauchli, Robert; De Saint Laumer, Jean-Yves
Helvetica Chimica Acta, 2013 , vol. 96, # 2 p. 246 - 258
反应条件
1: (i) Br2, CaCO3, (ii) LiBr, Li2CO3
2: (i) Li<N(SiMe3)2>, (ii) /BRN= 1857975/
3: CrO3, H2SO4
View Scheme
参考文献
Ravid; Ikan
Journal of Organic Chemistry, 1974 , vol. 39, # 17 p. 2637 - 2639
反应条件
1: TsOH
2: (i) Br2, CaCO3, (ii) LiBr, Li2CO3
3: (i) Li<N(SiMe3)2>, (ii) /BRN= 1857975/
4: CrO3, H2SO4
View Scheme
参考文献
Ravid; Ikan
Journal of Organic Chemistry, 1974 , vol. 39, # 17 p. 2637 - 2639
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C
2: boron trifluoride diethyl etherate / toluene / 20 h / 20 °C
View Scheme
参考文献
Winter, Beat; Chapuis, Christian; Brauchli, Robert; De Saint Laumer, Jean-Yves
Helvetica Chimica Acta, 2013 , vol. 96, # 2 p. 246 - 258
