4-氨基-3-甲氧基苯甲酸合成路线 （共 25 条）
反应条件
water in near-critical water;
参考文献
STRATEGIC ENZYME APPLICATIONS, INC.; ALBIZATI, Kim; TRACEWELL, Cara
Patent: WO2012/75053 A2, 2012 ;
Location in patent: Page/Page column 83-84 ;
反应条件
in near-critical water
参考文献
Strategic Enzyme Applications, Inc.
Patent: US2012/107886 A1, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
in super critical water Heating;
参考文献
Strategic Enzyme Applications, Inc.
Patent: US2012/107886 A1, 2012 ;
Location in patent: Page/Page column 20 ;
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; Substitution;
参考文献
Qian, Yimin; Marugan, Juan Jose; Fossum, Renae D.; Vogt, Andreas; Sebti, Said M.; Hamilton, Andrew D.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 12 p. 3011 - 3024
参考文献
THE WELLCOME FOUNDATION LIMITED; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: EP279698 A3, 1990 ;
反应条件
1: 1.) NaNO2, conc. HCl / 1.) H2O, 0-5 deg C, 1 h, 2.a) 50 deg C, 2.b) 2 h, reflux 2: SOCl2 / toluene / 3 h / Heating 3: 1.) THF, ether, 0-5 deg C, 1 h, 2.) dioxane, 2 h, reflux View Scheme
参考文献
Barraclough; Black; Cambridge; Demaine; Gerskowitch; Giles; Hill; Hull; Lyer; King; Livingstone; Nobbs; Randall; Shah; Whiting
Archiv der Pharmazie, 1990 , vol. 323, # 8 p. 507 - 512
反应条件
1: 1.) NaNO2, conc. HCl / 1.) H2O, 0-5 deg C, 1 h, 2.a) 50 deg C, 2.b) 2 h, reflux 2: SOCl2 / toluene / 3 h / Heating View Scheme
参考文献
Barraclough; Black; Cambridge; Demaine; Gerskowitch; Giles; Hill; Hull; Lyer; King; Livingstone; Nobbs; Randall; Shah; Whiting
Archiv der Pharmazie, 1990 , vol. 323, # 8 p. 507 - 512
反应条件
in methanol; ethyl acetate
参考文献
Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward
Patent: US2003/69284 A1, 2003 ;
US 20030069284 A1
反应条件
sulfuric acid
6 h; Heating;
参考文献
Taran; Renard; Bernard; Mioskowski; Frobert; Pradelles; Grassi
Journal of the American Chemical Society, 1998 , vol. 120, # 14 p. 3332 - 3339
参考文献
NeoRx Corporation
Patent: US6024937 A1, 2000 ;
