4-氨基-3-甲氧基苯甲酸合成路线 （共 25 条）
反应条件
ammonia; metal catalyst
参考文献
US2012/107886 A1, ;
Page/Page column 19 ;
反应条件
hydrogenchloride; tin
参考文献
Journal of the Chemical Society, , vol. 119, p. 1431
反应条件
1: durch Methylierung 2: ferrohydroxide; alkali View Scheme
参考文献
Journal of the Chemical Society, , vol. 111, p. 232
反应条件
1: acetic acid anhydride; HNO3+H2SO4 / -10 - -5 °C 2: tin; concentrated hydrochloric acid View Scheme
参考文献
Journal of the Chemical Society, , vol. 119, p. 1431
反应条件
1: SOCl2 / 2 h / 20 °C 2: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 3: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 4: 69 percent / CuI / dimethylformamide / 2.5 h / 100 °C 5: 95 percent / KOH; H2O / ethanol / 24 h / Heating 6: 65 percent / Cu2O / quinoline / 4 h / 230 °C View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
反应条件
trimethylsilyl bromide; phenylmethyltriethylammonium bromide; sodium nitrite in N,N-dimethyl-formamide T=0°C; 2 h;
参考文献
Mineno, Tomoko; Ueno, Tasuku; Urano, Yasuteru; Kojima, Hirotatsu; Nagano, Tetsuo
Organic Letters, 2006 , vol. 8, # 26 p. 5963 - 5966
反应条件
1: With sulfuric acid T=70°C; 24 h; 2: With sodium hydroxide in water pH=8;
参考文献
DECODE GENETICS EHF
Patent: US2009/130076 A1, 2009 ;
Location in patent: Page/Page column 31; 32 ;
US 20090130076 A1
反应条件
hydrogenchloride in methanol; ethyl acetate
参考文献
AGOURON PHARMACEUTICALS, INC.
Patent: EP1109560 B1, 2003 ;
反应条件
1: 98 percent / H2SO4 / 65 °C 2: 82 percent / ICl; NaHCO3 / CH2Cl2 / 0.5 h / 20 °C View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
反应条件
1: SOCl2 / 2 h / 20 °C 2: 99 percent / bis(pyridine)iodonium(I) tetrafluoroborate; CF3SO3H / CH2Cl2 / 16 h / 20 °C 3: 90 percent / Et3N / Pd(PPh3)2Cl2-CuI / 3 h / 0 - 20 °C 4: 69 percent / CuI / dimethylformamide / 2.5 h / 100 °C 5: 95 percent / KOH; H2O / ethanol / 24 h / Heating View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Lamas, Carlos; Barluenga, Jose; Perez, Marta; Garcia-Martin, Miguel Angel; Gonzalez, Jose M.
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 5804 - 5812
