2-甲基-苯并噻唑-5-羧酸合成路线 （共 10 条）
反应条件
1: With sodium hydroxide; silver nitrate in tetrahydrofuran; water T=20°C; 0.5 h; 2: With hydrogenchloride in water pH=3.5;
参考文献
EP1445249 A1, ;
Page 132 ;
反应条件
1: 4-chloro-3-nitro-benzoic acid With Na2S*9H2O in water T=120°C; 0.5 h; 2: acetic acid With acetic anhydride T=20°C; 2 h; Reflux;
参考文献
Huang, Qingqing; Mao, Jialin; Wan, Baojie; Wang, Yuehong; Brun, Reto; Franzblau, Scott G.; Kozikowski, Alan P.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6757 - 6767
参考文献
Zhurnal Obshchei Khimii, , vol. 22, p. 2209,2214; engl. Ausg. S. 2267, 2271
反应条件
1: 4-chloro-3-nitro-benzoic acid With sodium sulfide 0.333333 h; Heating; 2: acetic anhydride With acetic acid 0.333333 h; Heating;
参考文献
Klar, Ulrich; Buchmann, Bernd; Schwede, Wolfgang; Skuballa, Werner; Hoffmann, Jens; Lichtner, Rosemarie B.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 47 p. 7942 - 7948
反应条件
1: sodium nitrite; hydrogenchloride; potassium iodide / acetone; water 2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide 3: hydrogenchloride View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 19 p. 6205 - 6211
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide 2: hydrogenchloride View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 19 p. 6205 - 6211
参考文献
Zhurnal Obshchei Khimii, , vol. 22, p. 2209,2214; engl. Ausg. S. 2267, 2271
反应条件
sodium sulfide; sodium hydroxide; sulfur Erhitzen des Reaktionsprodukts mit Zink-Pulver und Acetanhydrid;
反应条件
1: zinc; aqueous HCl; acetic acid / anschliessendes Erhitzen mit Acetanhydrid 2: aqueous H2SO4 View Scheme
参考文献
Zhurnal Obshchei Khimii, , vol. 22, p. 2209,2214; engl. Ausg. S. 2267, 2271
反应条件
1: lithium aluminum hydride / tetrahydrofuran / 2 h / Heating 2: 94.7 percent / SO3*pyridine; DMSO; triethylamine / CH2Cl2 / 2 h / 23 °C View Scheme
参考文献
Klar, Ulrich; Buchmann, Bernd; Schwede, Wolfgang; Skuballa, Werner; Hoffmann, Jens; Lichtner, Rosemarie B.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 47 p. 7942 - 7948
