(S)-2,6-二叔丁氧羰基氨基己酸合成路线 （共 19 条）
反应条件
sodium hydroxide in 1,4-dioxane
参考文献
Driffield, Malcolm; Goodall, David M; Smith, David K
Organic and biomolecular chemistry, 2003 , vol. 1, # 14 p. 2612 - 2620
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Hirst, Andrew R.; Smith, David K.; Feiters, Martin C.; Geurts, Huub P. M.
Chemistry - A European Journal, 2004 , vol. 10, # 23 p. 5901 - 5910
反应条件
1: di-tert-butyl dicarbonate; anhydrous L-lysine monohydrochloride With sodium hydrogencarbonate in tetrahydrofuran; water T=0 - 20°C; 12 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran; water T=0 - 20°C; 12 h;
参考文献
Ghosh, Chandradhish; Manjunath, Goutham B.; Akkapeddi, Padma; Yarlagadda, Venkateswarlu; Hoque, Jiaul; Uppu, Divakara S.S.M.; Konai, Mohini M.; Haldar, Jayanta
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1428 - 1436
反应条件
1: anhydrous L-lysine monohydrochloride With water T=35°C; 2: di-tert-butyl dicarbonate With sodium hydroxide in water T=30 - 50°C; pH=> 8; 2 h;
参考文献
WO2006/121552 A2, ;
Page/Page column 28-29; 2/70 ;
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=20°C; pH=9 - 11; 6 h; 2: With citric acid in water pH=4 - 5;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 11 p. 5387 - 5397
参考文献
Journal of the American Chemical Society, , vol. 87, p. 611 - 619
反应条件
sodium hydroxide in tert-butyl alcohol
参考文献
Gazzetta Chimica Italiana, , vol. 94, p. 853 - 865
反应条件
sodium hydroxide in N,N-dimethyl-formamide
参考文献
Justus Liebigs Annalen der Chemie, , vol. 716, p. 216 - 218
反应条件
triethylamine in water; butan-1-ol
参考文献
Hoppe-Seyler's Zeitschrift fuer physiologische Chemie, , vol. 350, # 12 p. 1556 - 1562
参考文献
Gazzetta Chimica Italiana, , vol. 94, p. 743 - 759
反应条件
1: Py 2: aq. NaOH View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 94, p. 743 - 759
