拉喹莫德合成路线

637027-41-91,2-二氢-4-羟基-5-氯-1-甲基-2-氧代-喹啉-3-羧酸甲酯+

参考文献

ACTIVE BIOTECH AB
Patent: WO2003/106424 A1, 2003 ;
Location in patent: Page 6 ;

参考文献

MAPI PHARMA LTD.; MAROM, Ehud; MIZHIRITSKII, Michael; RUBNOV, Shai
Patent: WO2012/70051 A1, 2012 ;
Location in patent: Page/Page column 27 ;

103-69-5N-乙基苯胺+

335640-50-15-氯-4-羟基-1-甲基-2-氧代-1,2-二氢-3-喹啉羧酸

248281-84-7拉喹莫德

参考文献

Joensson, Stig; Andersson, Gunnar; Fex, Tomas; Fristedt, Tomas; Hedlund, Gunnar; Jansson, Karl; Abramo, Lisbeth; Fritzson, Ingela; Pekarski, Olga; Runstroem, Anna; Sandin, Helena; Thuvesson, Ingela; Bjoerk, Anders
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2075 - 2088

637027-41-91,2-二氢-4-羟基-5-氯-1-甲基-2-氧代-喹啉-3-羧酸甲酯+

103-69-5N-乙基苯胺

248281-84-7拉喹莫德

参考文献

ACTIVE BIOTECH AB; BOCK, Lillemor Maria; HOLMBERG, Paer Henning; JANSSON, Karl-Erik
Patent: WO2012/4338 A1, 2012 ;
Location in patent: Page/Page column 12; 15 ;

20829-96-35-氯-3,1-苯并噁嗪-2,4-二酮

248281-84-7拉喹莫德

参考文献

Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2075 - 2088

2148-56-32-氨基-6-氯苯甲酸

248281-84-7拉喹莫德

参考文献

Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2075 - 2088

40707-01-55-氯-1-甲基-1H-苯并[d][1,3]噁嗪-2,4-二酮

248281-84-7拉喹莫德

参考文献

Journal of Medicinal Chemistry, , vol. 47, # 8 p. 2075 - 2088