3,4-二甲氧基苯甲酸酐合成路线 （共 22 条）
反应条件
1.1: Et3N / 0.08 h / Heating
1.2: 74 percent / KOH / methanol / 0.33 h / sonication
2.1: 74 percent / K2CO3 / acetone / 5 h / Heating
View Scheme
参考文献
Daskiewicz, Jean-Baptiste; Depeint, Flore; Viornery, Lionel; Bayet, Christine; Comte-Sarrazin, Geraldine; Comte, Gilles; Gee, Jennifer M.; Johnson, Ian T.; Ndjoko, Karine; Hostettmann, Kurt; Barron, Denis
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2790 - 2804
反应条件
1: 1.) potassium benzoate, 2.) K2CO3 / 1.) 170/180 deg C, 8 h, 2.) acetone, reflux, 2.5-4 h
2: 95 percent / AlBr3 / acetonitrile / 0.33 h / 0 - 5 °C
3: 95 percent / K2CO3 / acetone / Heating
4: 91 percent / AlBr3 / acetonitrile / 1 h / Ambient temperature
5: 88 percent / K2CO3 / methanol / 2 h / Heating
View Scheme
参考文献
Horie, Tokunaru; Kawamura, Yasuhiko; Tsukayama, Masao; Yoshizaki, Shiro
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 5 p. 1216 - 1220
