4-羟基-2-乙基喹啉羧酸酯合成路线 （共 14 条）
反应条件
benzene Erhitzen des Reaktionsprodukts mit Diphenylaether;
参考文献
Journal of the American Chemical Society, , vol. 68, p. 2685
反应条件
polyphosphoric acid T=120°C; 1 h; Inert atmosphere;
参考文献
Stevenson, Louise; Tavares, Adriana A.S.; Brunet, Aurelie; McGonagle, Fiona I.; Dewar, Deborah; Pimlott, Sally L.; Sutherland, Andrew
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 3 p. 954 - 957
反应条件
1: toluene-4-sulfonic acid / cyclohexane / 48 h / |Inert atmosphere; |Reflux; |Dean-Stark 2: polyphosphoric acid / 1 h / 120 °C / |Inert atmosphere View Scheme
参考文献
MedChemComm, , vol. 4, # 11 p. 1461 - 1466
反应条件
1: toluene-4-sulfonic acid / cyclohexane / 48 h / |Inert atmosphere; |Reflux; |Dean-Stark 2: polyphosphoric acid / 1 h / 120 °C / |Inert atmosphere View Scheme
参考文献
MedChemComm, , vol. 4, # 11 p. 1461 - 1466
反应条件
hydrogenchloride; palladium Hydrogenation;
参考文献
Gazzetta Chimica Italiana, , vol. 80, p. 161,169
反应条件
1: sodium ethylate 2: aqueous HCl 3: palladium; ethanolic HCl / Hydrogenation View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 80, p. 161,169
反应条件
1: aqueous HCl 2: palladium; ethanolic HCl / Hydrogenation View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 80, p. 161,169
反应条件
1: concentrated H2SO4; HNO3 / 0 °C 2: SnCl2; aqueous HCl 3: quinoline; copper-powder View Scheme
参考文献
Kermack; Weatherhead
Journal of the Chemical Society, 1940 , p. 1164,1168
反应条件
1: PBr5 / 120 °C 2: aqueous NaOH View Scheme
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; SCHLEGEL, Kelly-Ann; YANG, Zhi-Qiang
Patent: WO2011/84368 A1, 2011 ;
WO 2011/084368 A1
反应条件
1: acetic acid; ICl / 80 °C 2: aqueous NaOH 3: diphenyl ether; biphenyl / 180 °C 4: phosphoryl chloride View Scheme
参考文献
Surrey; Cutler
Journal of the American Chemical Society, 1946 , vol. 68, p. 2570,2573
