2-氨基-5-甲氧基苯甲酸甲酯合成路线 （共 16 条）
反应条件
1.1: Heating 2.1: tetrahydrofuran / -78 °C 2.2: AcOH / 20 °C 3.1: POCl3 / Heating View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: Heating 2.1: tetrahydrofuran / -78 °C 2.2: AcOH / 20 °C View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
反应条件
1.1: 82 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2.1: 91 percent / DIBAL / toluene / 1 h / -78 °C 3.1: 91 percent / MnO2 / benzene / 4 h / Heating 4.1: 97 percent / K2CO3 / dimethylformamide / 1 h / 80 °C 5.1: KN(TMS)2 / tetrahydrofuran / 0.25 h / -78 °C 5.2: 98 percent / tetrahydrofuran / 1 h / -78 - 20 °C 6.1: 95 percent / Cl2Ru(=CHPh)(PCy3)2 / CH2Cl2 / 1 h / 50 °C View Scheme
参考文献
Arisawa, Mitsuhiro; Theeraladanon, Chumpol; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron Letters, 2001 , vol. 42, # 45 p. 8029 - 8033
反应条件
1.1: Heating
2.1: tetrahydrofuran / -78 °C
2.2: AcOH / 20 °C
View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
参考文献
Sevbo, D. P.; Stepanova, T. F.; Nekhoroshev, A. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, p. 1097 - 1101
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 6 p. 1268 - 1274
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 25°C; 2.41667 h;
2: With sodium hydroxide; water in tetrahydrofuran
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1844768 A1, 2007 ;
Location in patent: Page/Page column 26 ;
