3-(3-甲氧基苯基)-1-丙烯合成路线 （共 25 条）
反应条件
1: With boron tribromide in dichloromethane T=0°C; 3 h; 2: With water in dichloromethane
参考文献
MEDIVIR AB
Patent: WO2008/135488 A1, 2008 ;
Location in patent: Page/Page column 43; 44 ;
WO 2008/135488 A1
反应条件
1: 3-methoxybromobenzene With iodine; magnesium in diethyl ether
Inert atmosphereReflux;
2: allyl bromide in diethyl ether
T=0 - 20°C; 2.08333 h; Inert atmosphere;
参考文献
Taber, Douglass F.; Paquette, Craig M.; Gu, Peiming; Tian, Weiwei
Journal of Organic Chemistry, 2013 , vol. 78, # 19 p. 9772 - 9780
反应条件
1: ethylene,methyl acetate With indium(III) chloride; dimethyl(n-butyl)amine; lithium chloride; indium; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=35°C;
2: 3-methoxy-iodobenzene in N,N-dimethyl-formamide
T=100°C;
参考文献
Seomoon, Dong; Lee, Kooyeon; Kim, Hyunseok; Lee, Phil Ho
Chemistry - A European Journal, 2007 , vol. 13, # 18 p. 5197 - 5206
反应条件
indium(III) chloride; indium; lithium chloride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide
T=100°C; 6 h;
参考文献
Seomoon, Dong; Phil, Ho Lee
Journal of Organic Chemistry, 2008 , vol. 73, # 3 p. 1165 - 1168
反应条件
indium(III) chloride; indium; lithium chloride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide
T=100°C; 6 h;
参考文献
Seomoon, Dong; Phil, Ho Lee
Journal of Organic Chemistry, 2008 , vol. 73, # 3 p. 1165 - 1168
反应条件
1: n-propyl-magnesium bromide With zirconocene dichloride in tetrahydrofuran
T=0°C; 0.5 h;
2: With 2,4-dimethylpentan-3-one in tetrahydrofuran
T=25°C; 3 h;
3: 3-methoxy-iodobenzene With NiBr2(PPh3)2 in tetrahydrofuran
T=25°C; 3 h;
参考文献
Hirano, Koji; Fujita, Kazuya; Yorimitsu, Hideki; Oshima, Koichiro
Synlett, 2005 , # 11 art. no. Y00705ST, p. 1787 - 1788
反应条件
bis(1,5-cyclooctadiene)nickel (0); triethylsilyl trifluoromethanesulphonate; triethylamine; diphenylcyclohexyl phosphine in toluene
T=20°C; Heck type reaction; P=760.051 Torr; 2 h;
参考文献
Matsubara, Ryosuke; Gutierrez, Alicia C.; Jamison, Timothy F.
Journal of the American Chemical Society, 2011 , vol. 133, # 47 p. 19020 - 19023
反应条件
in tetrahydrofuran
T=20°C; 24 h;
参考文献
Yan, Bingli; Spilling, Christopher D.
Journal of Organic Chemistry, 2004 , vol. 69, # 8 p. 2859 - 2862
反应条件
triphenylphosphine; CoCl2 in tetrahydrofuran
T=20°C; 2 h;
参考文献
Ohmiya, Hirohisa; Tsuji, Takashi; Yorimitsu, Hideki; Oshima, Koichiro
Chemistry - A European Journal, 2004 , vol. 10, # 22 p. 5640 - 5648
反应条件
potassium hydroxide; 2C8H8NO2(1-)*2Cl(1-)*2Pd(2+); tetrabutylammomium bromide in water; acetone
T=50°C; Suzuki-Miyaura coupling; 14 h;
参考文献
Alacid, Emilio; Najera, Carmen
Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2321 - 2327
