1: enolate sodique de l'acetylacetate d'ethyle With n-butyllithium in tetrahydrofuran; hexane 0.333333 h; 2: (Z)-1-bromo-3,7-dimethyl-octa-2,6-diene in tetrahydrofuran; hexane T=0°C; 0.5 h; Further stages.;

n-butyllithium; sodium hydride in tetrahydrofuran; hexane T=0 - 20°C; 0.5 h;

in tetrahydrofuran; hexane T=0°C; 0.5 h;

1: 60 percent / KN(SiMe3)2 / dimethylformamide; toluene / 3.5 h / 0 °C 2: 64 percent / CuI; Ph3As; bis(benzonitrile)palladium(II) chloride / 1-methyl-pyrrolidin-2-one / 15 h / 100 °C 3: 74 percent / DIBAL-H / toluene / 1 h / -78 °C View Scheme

1: 86 percent / KN(SiMe3)2 / tetrahydrofuran; toluene / -78 - 20 °C 2: 85 percent / CuI; Ph3As; bis(benzonitrile)palladium(II) chloride / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C 3: 62 percent / DIBAL-H / toluene / 1 h / -78 °C View Scheme