2-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮合成路线

参考文献

Jackson, Delwin S.; Fraser, Stephanie A.; Ni, Li-Ming; Kam, Chih-Min; Winkler, Ulrike; Johnson, David A.; Froelich, Christopher J.; Hudig, Dorothy; Powers, James C.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2289 - 2301

13325-10-54-氨基-1-丁醇+

22509-74-6N-乙氧羰基邻苯二甲酰亚胺

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

参考文献

The DuPont Merck Pharmaceutical Company
Patent: US5710159 A1, 1998 ;

136918-14-4+

928-51-84-氯丁醇

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

参考文献

Feller, Dennis R.; Miller, Duane D.
Patent: US2004/19079 A1, 2004 ;
Location in patent: Page/Page column 27 ;
US 20040019079 A1

928-51-84-氯丁醇+

1074-82-4邻苯二甲酰亚胺钾

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

参考文献

Zheng, Weiping; Nikulin, Victor I.; Konkar, Anish A.; Vansal, Sandeep S.; Shams, Gamal; Feller, Dennis R.; Miller, Duane D.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 12 p. 2287 - 2294

102022-69-5

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

参考文献

Bergmann; Kaluszyner
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 289,309

136918-14-4

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

参考文献

Bergmann; Kaluszyner
Recueil des Travaux Chimiques des Pays-Bas, 1959 , vol. 78, p. 289,309

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

5394-18-3N-(4-溴丁基)邻苯二甲酰亚胺

参考文献

TOPOTARGET A/S; CHRISTENSEN, Mette Knak; BJOeRKLING, Fredrik
Patent: WO2011/121055 A1, 2011 ;
Location in patent: Page/Page column 24 ;
WO 2011/121055 A1

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

3598-60-54-(1,3-二氧代异吲哚啉-2-基)丁醛

参考文献

Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1640369 A1, 2006 ;
Location in patent: Page/Page column 26 ;

79-37-8草酰氯+

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

3598-60-54-(1,3-二氧代异吲哚啉-2-基)丁醛

参考文献

The DuPont Merck Pharmaceutical Company
Patent: US5710159 A1, 1998 ;

24697-70-92-(4-羟基丁基)-1H-异吲哚-1,3(2H)-二酮

136604-50-7

参考文献

Eriks; Van der Goot; Sterk; Timmerman
Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3239 - 3246