3,4-二氯-5-甲基-1H-吡咯-2-羧酸乙酯合成路线 （共 3 条）
反应条件
sulfuryl dichloride in tetrachloromethane T=0°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/92608 A1, 2006 ;
Location in patent: Page/Page column 54 ;
WO 2006/092608 A1
反应条件
sodium cyanoborohydride in 1-methyl-pyrrolidin-2-one T=20 - 80°C; Product distribution / selectivity;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/87543 A1, 2006 ;
Location in patent: Page/Page column 76-77 ;
WO 2006/087543 A1
反应条件
1: With methanol; lithium hydroxide; water in dichloromethane T=70°C; 2 h; 2: With hydrogenchloride; water in methanol; dichloromethane T=0°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/92608 A1, 2006 ;
Location in patent: Page/Page column 53-54 ;
WO 2006/092608 A1
