4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-甲酸乙酯 1,1-二氧化物合成路线 （共 14 条）
反应条件
sodium hydroxide in ethanol T=20°C; 18 h;
参考文献
Koczian, Kristof; Voelgyi, Gergely; Koekoesi, Jozsef; Noszal, Bela
Helvetica Chimica Acta, 2007 , vol. 90, # 9 p. 1681 - 1690
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78°C; 5.5 h;
参考文献
Patek, Marcel; Hampl, Frantisek
Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 12 p. 3267 - 3277
反应条件
1: 68 percent / EtONa / ethanol / 1 h / 55 °C 2: 72 percent / aq. NaOH / ethanol / 18 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 90, # 9 p. 1681 - 1690
反应条件
1: 4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide With sodium hydroxide in ethanol; water 2: methyl halide in ethanol; water T=20°C; 12 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 3 p. 1065 - 1069
反应条件
1: 72 percent / dimethylformamide / 3 h / 100 °C 2: 68 percent / EtONa / ethanol / 1 h / 55 °C 3: 72 percent / aq. NaOH / ethanol / 18 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 90, # 9 p. 1681 - 1690
反应条件
in xylene 24 h; Heating;
参考文献
Zinnes; Sircar; Lindo; Schwartz; Fabian; Shavel Jr.; Kasulanis; Genzer; Lutomski; DiPasquale
Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 12 - 18
参考文献
Boehringer Ingelheim GmbH
Patent: US4233299 A1, 1980 ;
US 4233299 A
反应条件
in o-xylene 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
McElroy, Liam; Cromie, Lillian; Garret, Mark
Patent: US2008/119647 A1, 2008 ;
Location in patent: Page/Page column 2 ;
反应条件
in xylene T=139 - 140°C; 32 - 37 h;
参考文献
Vigano, Enrico; Landonio, Ernesto
Patent: US2006/116514 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
carbon in xylene T=170 - 180°C; 24 h; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: WO2006/64298 A1, 2006 ;
Location in patent: Page 234 ;
