2,3-二氢-3-氧代-1,2-苯并异噻唑-2-乙酸乙酯-1,1-二氧化物合成路线 （共 20 条）
反应条件
1: 68 percent / EtONa / ethanol / 1 h / 55 °C 2: 72 percent / aq. NaOH / ethanol / 18 h / 20 °C 3: 56 percent / dimethylformamide / 12 h / 140 - 150 °C View Scheme
参考文献
Koczian, Kristof; Voelgyi, Gergely; Koekoesi, Jozsef; Noszal, Bela
Helvetica Chimica Acta, 2007 , vol. 90, # 9 p. 1681 - 1690
反应条件
1: 68 percent / EtONa / ethanol / 1 h / 55 °C 2: 72 percent / aq. NaOH / ethanol / 18 h / 20 °C 3: 57 percent / dimethylformamide / 12 h / 140 - 150 °C View Scheme
参考文献
Koczian, Kristof; Voelgyi, Gergely; Koekoesi, Jozsef; Noszal, Bela
Helvetica Chimica Acta, 2007 , vol. 90, # 9 p. 1681 - 1690
反应条件
1: 68 percent / EtONa / ethanol / 1 h / 55 °C 2: 72 percent / aq. NaOH / ethanol / 18 h / 20 °C 3: 64 percent / dimethylformamide / 12 h / 140 - 150 °C View Scheme
参考文献
Koczian, Kristof; Voelgyi, Gergely; Koekoesi, Jozsef; Noszal, Bela
Helvetica Chimica Acta, 2007 , vol. 90, # 9 p. 1681 - 1690
反应条件
1: 68 percent / EtONa / ethanol / 1 h / 55 °C 2: 72 percent / aq. NaOH / ethanol / 18 h / 20 °C 3: 60 percent / dimethylformamide / 12 h / 140 - 150 °C View Scheme
参考文献
Koczian, Kristof; Voelgyi, Gergely; Koekoesi, Jozsef; Noszal, Bela
Helvetica Chimica Acta, 2007 , vol. 90, # 9 p. 1681 - 1690
反应条件
1: 68 percent / EtONa / ethanol / 1 h / 55 °C 2: 72 percent / aq. NaOH / ethanol / 18 h / 20 °C View Scheme
参考文献
Rasmussen,C.R.
Journal of Organic Chemistry, 1974 , vol. 39, p. 1554 - 1560
反应条件
1: NaOEt / ethanol 2: aq. NH3 3: NaOMe / dimethylformamide View Scheme
参考文献
Rasmussen,C.R.
Journal of Organic Chemistry, 1974 , vol. 39, p. 1554 - 1560
反应条件
sodium ethanolate in ethanol
T=55°C; Gabriel-Colman rearrangement; 1 h;
参考文献
Koczian, Kristof; Voelgyi, Gergely; Koekoesi, Jozsef; Noszal, Bela
Helvetica Chimica Acta, 2007 , vol. 90, # 9 p. 1681 - 1690
反应条件
in ethanol
0.05 h; Heating;
参考文献
Schapira, Celia B.; Perillo, Isabel A.; Lamdan, Samuel
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1281 - 1288
反应条件
1: 76 percent / methanol
2: 70 percent / 40percent sodium hydroxide / H2O / 28 h / Ambient temperature
3: H2O / recrystallization
View Scheme
参考文献
Schapira, Celia B.; Perillo, Isabel A.; Lamdan, Samuel
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1281 - 1288
反应条件
hydrogenchloride in water
T=90°C;
参考文献
D'Ascenzio, Melissa; Carradori, Simone; De Monte, Celeste; Secci, Daniela; Ceruso, Mariangela; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 6 p. 1821 - 1831
