反应条件
1: 1.) MnO2 2.) (carbethoxymethylene)triphenylphosphorane / 1.) CH2Cl2, rt, 1 h 2.) CH2Cl2, reflux, 18 h 2: 1.) NaH / 1.) DMF, 0 deg C 2.) 2 h 3: H2 / 10percent Pd-C / ethanol / 1 h / Ambient temperature View Scheme
参考文献
Zaghdane, Helmi; Boyd, Michael; Colucci, John; Simard, Daniel; Berthelette, Carl; Leblanc, Yves; Wang, Zhaoyin; Houle, Robert; Levesque, Jean Francois; Molinaro, Carmela; Hamel, Martine; Stocco, Rino; Sawyer, Nicole; Sillaots, Susan; Gervais, Francois; Gallant, Michel
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 11 p. 3471 - 3474
